2024-03-29T14:00:34Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/68492021-06-23T09:50:57Zcom_10324_1134com_10324_931com_10324_894col_10324_1213
Differential stimulus coupling to dopamine and norepinephrine stores in rabbit carotid body type I cells
Gómez Niño, María Ángeles
Dinger, Bruce
González, Constancio
Fidone, Salvatore
Neurofisiología
Recent studies suggest that preneural type I (glomus) cells in the arterial chemoreceptor tissue of the carotid body act as primary transducer
elements which respond to natural stimuli (low 02, pH or increased CO2) by releasing chemical transmitter agents capable of exciting the closely
apposed afferent nerve terminals. These type I cells contain multiple putative transmitters, but the identity of the natural excitatory agents
remains an unresolved problem in carotid body physiology. Characterization of putative transmitter involvement in the response to natural
and pharmacological stimuli has therefore become fundamental to further understanding of chemotransmission in this organ. The present study
demonstrates that a natural stimulus (hypoxia) evokes the release of dopamine (DA) and norepinephrine (NE) in approximate proportion to
their unequal stores in rabbit carotid body (DA release/NE release = 8.2). In contrast, nicotine (100/~M), a cholinornimetic agent thought
to act on the nicotinic receptors present on the type I cells, evokes the preferential release of NE (DA release/NE release = 0.17). These
findings suggest that distinct mechanisms are involved in a differential mobilization of these two cateeholamines from the rabbit carotid body.
2014-11-03T09:28:55Z
2014-11-03T09:28:55Z
1990
info:eu-repo/semantics/article
Brain Research 525(1990) 160-164
0006-8993
http://uvadoc.uva.es/handle/10324/6849
160
164
Brain Research
525
eng
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Elsevier
SI