2024-03-29T06:56:58Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/77482021-06-23T09:48:47Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
Embryonic Cerebrospinal Fluid Activates Neurogenesis of Neural Precursors within the Subventricular Zone of the Adult Mouse Brain
Carnicero Gila, Estela María
Alonso Revuelta, María Isabel
Carretero Soto, Raquel
Lamus Molina, José Francisco
Moro Balbás, José Antonio
Mano Bonín, Anibal de la
Fernández Gómez, José María Fidel
Gato Casado, Ángel Luis
Neurorregeneración
Embriología
Producción Científica
Introduction: There is a nondeveloped neurogenic potential
in the adult mammalian brain, which could be the basis for
neuroregenerative strategies. Many research efforts have
been made to understand the control mechanisms which
regulate the transition from a neural precursor to a neuron
in the adult brain. Embryonic cerebrospinal fluid (CSF) is a
complex fluid which has been shown to play a key role in
neural precursor behavior during development, working as
a powerful neurogenic inductor. We tested if the neurogenic
properties of embryonic CSF are able to increase the neurogenic
activity of neuronal precursors from the subventricular
zone (SVZ) in the brains of adult mice. Results: Our results
show that mouse embryonic CSF significantly increases
the neurogenic activity in precursor cells from adult brain
SVZ. This intense neurogenic effect was specific for embryonic
CSF and was not induced by adult CSF. Conclusions:
Embryonic CSF is a powerful neurogenesis inductor in homologous
neuronal precursors in the adult brain. This property
of embryonic CSF could be a useful tool in neuroregeneration
strategies.
2014-12-18T12:47:03Z
2014-12-18T12:47:03Z
2013
info:eu-repo/semantics/article
Cell Tissues Organs, 2013, 198(5) 398-404
1422-6405
http://uvadoc.uva.es/handle/10324/7748
10.1159/000356983
398
198
404
Cells Tissues Organs
5
eng
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Karger
SI