2024-03-28T16:23:28Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/101362021-06-23T09:49:30Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
Sasahara, Yoji
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Rachid, Rima
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Byrne, Michael J.
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500
Abraham, Robert T.
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500
Ramesh, Narayanaswamy
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Geha, Raif S.
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Fuente García, Miguel Ángel de la
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2015-03-27T09:03:44Z
2015-03-27T09:03:44Z
2002
Molecular Cell, 2002, vol. 10, n. 6. p. 1269-1281
1097-2765
http://uvadoc.uva.es/handle/10324/10136
10.1016/s1097-2765(02)00728-1
1269
6
1281
Molecular Cel
10
Producción Científica
F-actin polymerization following engagement of the T cell receptor (TCR) is dependent on WASP and is critical for T cell activation. The link between TCR and WASP is not fully understood. In resting cells, WASP exists in a complex with WIP, which inhibits its activation by Cdc42. We show that the adaptor protein CrkL binds directly to WIP. Further, TCR ligation results in the formation of a ZAP-70-CrkL-WIP-WASP complex, which is recruited to lipid rafts and the immunological synapse. TCR engagement also causes PKCtheta-dependent phosphorylation of WIP, causing the disengagement of WASP from the WIP-WASP complex, thereby releasing it from WIP inhibition. These results suggest that the ZAP-70-CrkL-WIP pathway and PKCtheta link TCR to WASP activation.
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eng
Elsevier
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Attribution-NonCommercial-ShareAlike 4.0 International
Biología molecular
Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation
info:eu-repo/semantics/article
https://www.sciencedirect.com/science/article/pii/S1097276502007281?via%3Dihub
SI
THUMBNAIL
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2021-06-23 11:49:30.143
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