2024-03-28T17:36:17Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/101522022-06-28T07:30:28Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
Martín, Margarita
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500
Romero, Xavier
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500
Fuente García, Miguel Ángel de la
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500
Tovar, Victoria
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500
Zapater, Nuria
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500
Esplugues, Enric
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500
Pizcueta, Pilar
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500
Bosch, Jaime
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500
Engel, Pablo
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500
2015-04-08T11:33:45Z
2015-04-08T11:33:45Z
2001
The Journal of Immunology 2001, 167(7): 3668–3676.
0022-1767
http://uvadoc.uva.es/handle/10324/10152
10.4049/jimmunol.167.7.3668
3668
7
3676
The Journal of Immunology
167
Producción Científica
CD84 is a member of the CD2 subset of the Ig superfamily of cell surface molecules. Its cytoplasmic tail binds to Src homology 2 domain-containing protein 1A (signaling lymphocytic activation molecule-associated protein), a protein encoded by the X-linked lymphoproliferative disease gene. It is preferentially expressed on B lymphocytes, monocytes, and platelets. We show that it is also expressed on thymocytes and T cells. CD84 was positive on CD4 CD8 thymocytes, and its expression decreased with cell maturation. It is expressed on mature T cells preferentially on CD45RO . To identify the CD84 ligand, we generated a soluble
Ig fusion protein containing the human CD84 extracellular domains (CD84-Ig). Because receptor-ligand interactions occur between several members of this subfamily, we assayed CD84-Ig binding with all members of the CD2 family. CD84-Ig bound to CD84-transfected cells, whereas no binding was detected with cells expressing other CD2 subfamily receptors, showing that CD84 binds to itself. Anti-CD84 mAbs recognizing epitopes wholly within domain 1 of CD84 blocked the binding of the CD84-Ig fusion protein to CD84-transfected cells and platelets. Data from CD84 domain human/mouse chimeras further revealed that only the first extracellular domain of the molecule is involved in the ligand receptor recognition. The CD84-CD84 interaction was independent of its cytoplasmic tail. Finally, concurrent ligation of human CD84 with mAbs or CD84-Ig and CD3 enhanced IFN-secretion in human lymphocytes. Thus, CD84 is its own ligand and acts as a costimulatory molecule.
application/pdf
eng
American Association of Immunologists
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Biología molecular
CD84 Functions as a homophilic adhesion molecule and enhances IFN- g secretion:adhesion is mediated by Ig-like domain 1
info:eu-repo/semantics/article
SI
ORIGINAL
17.M.A. de la Fuente PD-230.pdf
17.M.A. de la Fuente PD-230.pdf
PD-230
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2022-06-28 09:30:28.661
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