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oai:uvadoc.uva.es:10324/215952021-06-23T09:55:48Zcom_10324_1138com_10324_931com_10324_894col_10324_1226

Labrador Velandia, Sonia Cecilia 1ecc7c53-87c7-4763-bee6-a55642c7834a 500 Alonso Alonso, María Luz 1b1d02db-9513-4a25-b440-bf5fe485c71c 500 Álvarez Sánchez, Sara 65ec555c-0695-414e-8c74-4959f5d6a748 500 González Zamora, Jorge ec2c163e-bebe-4909-882d-b26742b8cef8 500 Pastor Jimeno, José Carlos 3a21b8dd8958866c 500 Fernández Bueno, Iván cccbebf247451cbb 500 Srivastava, Girish Kumar 06b0037ee6accaeb 500 0000-0002-9791-4057 2016-12-13T13:04:33Z 2016-12-13T13:04:33Z 2016 World Journal of Stem Cells 2016, 26; 8(11), p. 376-383 1948-0210 http://uvadoc.uva.es/handle/10324/21595 10.4252/wjsc.v8.i11.376 376 383 World Journal of Stem Cells Producción Científica Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells (MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseases Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA066U13) application/pdf eng Baishideng Publishing Group info:eu-repo/semantics/openAccess © 2016 Baishideng Publishing Group Inc. Células madre Retina Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials info:eu-repo/semantics/article http://www.wjgnet.com/1948-0210/index.htm SI ORIGINAL WJSC-8-376.pdf WJSC-8-376.pdf application/pdf 743555 https://uvadoc.uva.es/bitstream/10324/21595/1/WJSC-8-376.pdf c90eaf083be66975c9712a27fdacae46 MD5 1 LICENSE license.txt license.txt text/plain 4250 https://uvadoc.uva.es/bitstream/10324/21595/2/license.txt 909e634ba52becf192e4e9b4bcde7863 MD5 2 THUMBNAIL WJSC-8-376.pdf.jpg WJSC-8-376.pdf.jpg IM Thumbnail image/jpeg 3016 https://uvadoc.uva.es/bitstream/10324/21595/3/WJSC-8-376.pdf.jpg 8060cbf0ddf5eb64bca66e08ee4b3355 MD5 3 10324/21595 oai:uvadoc.uva.es:10324/21595 2021-06-23 11:55:48.104 UVaDOC repositorio@uva.es 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