2024-03-29T02:18:33Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/228482021-07-06T08:34:12Zcom_10324_22821com_10324_954com_10324_894com_10324_1185com_10324_931col_10324_22822col_10324_1346
Fernández Colino, Alicia
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Bermúdez, J. M.
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Arias Vallejo, Francisco Javier
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0000-0001-8584-3768
Quinteros, Daniela A.
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Gonzo, E.
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2017-03-29T11:30:47Z
2017-03-29T11:30:47Z
2015
Materials Science and Engineering, April 2016, vol. 61, n. 1 , p. 286–292
0928-4931
http://uvadoc.uva.es/handle/10324/22848
http://dx.doi.org/10.1016/j.msec.2015.12.050
Producción Científica
Transversality between mathematical modeling, pharmacology, and materials science is essential in order to achieve controlled-release systems with advanced properties. In this regard, the area of biomaterials provides a platform for the development of depots that are able to achieve controlled release of a drug, whereas pharmacology strives to find new therapeutic molecules and mathematical models have a connecting function, providing a rational understanding by modeling the parameters that influence the release observed. Herein we present a mechanism which, based on reasonable assumptions, explains the experimental data obtained very well. In addition, we have developed a simple and accurate “lumped” kinetics model to correctly fit the experimentally observed drug release behavior. This lumped model allows us to have simple analytic solutions for the mass and rate of drug release as a function of time without limitations of time or mass of drug released, which represents an important step-forward in the area of in vitro drug delivery when compared to the current state of the art in mathematical modeling. As an example, we applied the mechanism and model to the release data for acetazolamide from a recombinant polymer. Both materials were selected because of a need to develop a suitable ophthalmic formulation for the treatment of glaucoma. The in vitro release model proposed herein provides a valuable predictive tool for ensuring product performance and batch-to-batch reproducibility, thus paving the way for the development of further pharmaceutical devices.
Este trabajo forma parte de los Proyectos de Investigación financiados por la Comisión Europea a través del Fondo Social Europeo (FSE) y de la Consejería de Educación mediante el Fondo Europeo de Desarrollo Regional (ERDF), el MINECO (Proyectos MAT2013-41723-R, MAT2013-42473-R, PRI−PIBAR-2011-1403 y MAT2012-38043), la Junta de Castilla y León (Proyectos VA155A12, VA152A12, and VA244U13), el CIBER-BBN y el Instituto de Salud Carlos III mediante el Centro de Medicina Regenerativa y Terapia Celular de Castilla y León.
application/pdf
spa
Elsevier
info:eu-repo/semantics/openAccess
Biomateriales - Aplicaciones médicas
Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel
info:eu-repo/semantics/article
SI
ORIGINAL
Prueba 1.pdf
Prueba 1.pdf
A. Fernandez-Colino, J.M. Bermudez, F.J. Arias, D. Quinteros, E. Gonzo
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https://uvadoc.uva.es/bitstream/10324/22848/1/Prueba%201.pdf
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LICENSE
license.txt
license.txt
text/plain
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https://uvadoc.uva.es/bitstream/10324/22848/2/license.txt
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THUMBNAIL
Prueba 1.pdf.jpg
Prueba 1.pdf.jpg
IM Thumbnail
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oai:uvadoc.uva.es:10324/22848
2021-07-06 10:34:12.946
UVaDOC
repositorio@uva.es
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