2024-03-29T08:43:48Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/403782021-06-24T07:27:50Zcom_10324_22821com_10324_954com_10324_894col_10324_22822
Piña Lancho, María Jesús
f084072d-0df1-4ac2-a8be-6ab83f8cc7f3
500
Girotti, Alessandra
d4d2b14d-43a4-467c-9955-20dd81a433f5
500
Serrano, Sofía
dd7e1255-edee-46bd-a833-850a0934769a
500
Muñoz Martínez, Raquel
30d13e8260075711
500
0000-0001-9861-0349
Rodríguez Cabello, José Carlos
d05e9dc813a44ad8
500
0000-0002-3438-858X
Arias Vallejo, Francisco Javier
029dd751c638df83
500
0000-0001-8584-3768
2020-01-29T09:15:49Z
2020-01-29T09:15:49Z
2020
Cancer Letters, 2020, vol. 470. p. 43-53
0304-3835
http://uvadoc.uva.es/handle/10324/40378
10.1016/j.canlet.2019.11.031
Producción Científica
The complexity and continuous evolution of cancer make the design of novel strategies of treatment a constant challenge in biomedicine. Moreover, most of cancer treatments are still not tumor-specific and provoke high systemic toxicity. Herein we have developed a novel selective nanodevice to eliminate tumor cells while leaving healthy ones intact. To achieve this objective, a polyplex carrier, comprising an elastin like-recombinamer covalently conjugated to an aptamer and complexed with therapeutic DNA, was tested. This carrier forms a double-lock multifunctional device due to specific binding to a tumor cell marker and the selective expression of therapeutic DNA inside human breast-cancer cells. Due to the stability provided by ELRs, the homogeneous population of polyplexes obtained showed selective toxicity against cancer cells in in vitro and in vivo assay. Inhibition of tumor progression was detected early being very significant at the end point, with a dose-dependent reduction in tumor mass. Histological studies revealed a specific reduction in tumor parenchyma and in specific tumor cell markers. These results represent an important step toward the rational development of an efficient, safe and more specialized gene-delivery device for tumor therapy.
Fondo Social Europeo - FEDER- Unión Europea (project MP-2014-646075
Ministerio de Economía, Industria y Competitividad (project PCIN-2015-010 / MAT2015-68901-R / MAT2016-78903-R)
Junta de Castilla y León (project VA317P18)
application/pdf
eng
Elsevier
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2020 Elsevier
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Elastin-like recombinamers
Recombinantes tipo elastina
Nanocarriers
Nanoportadores
Suicide gene therapy
Terapia génica suicida
Breast cancer
Cáncer de mama
A double safety lock tumor-specific device for suicide gene therapy in breast cancer
info:eu-repo/semantics/article
info:eu-repo/semantics/draft
https://www.sciencedirect.com/science/article/pii/S0304383519305865
SI
THUMBNAIL
Double-safety-lock-tumor-manuscript.pdf.jpg
Double-safety-lock-tumor-manuscript.pdf.jpg
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LICENSE
license.txt
license.txt
text/plain
3926
https://uvadoc.uva.es/bitstream/10324/40378/3/license.txt
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Double-safety-lock-tumor-manuscript.pdf
Double-safety-lock-tumor-manuscript.pdf
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2021-06-24 09:27:50.208
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