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oai:uvadoc.uva.es:10324/441402021-06-24T07:25:41Zcom_10324_41462com_10324_954com_10324_894col_10324_41463

Soriano, Vicente ea348a2a-30ee-4806-bb05-700957e24abb 500 Barreiro, Pablo e835ba29-77a8-4ece-9869-59900760e8a0 500 Ramos, José Manuel b3ba99d9-c1d3-49cc-b003-c5f74fdcfd77 500 Eiros Bouza, José María 8352bd45ebf87498 500 Mendoza, Carmen de c161888c-0d6d-4b9e-948f-f6f083161b6f 500 2020-12-14T12:22:50Z 2020-12-14T12:22:50Z 2020 AIDS Reviews, 2020, vol. 22, n.2, p. 63-77 1139-6121 http://uvadoc.uva.es/handle/10324/44140 10.24875/AIDSRev.M20000030 63 2 77 Aids Reviews 22 1481-4374 Producción Científica The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit health-care systems and societies in an unprecedented manner. In 1981, the first cases of AIDS were reported and wide diagnostic testing helped to characterize high-risk groups and the global burden of the epidemic. With Coronavirus Disease (COVID)-19, everything has happened too fast and both cases and fatalities are huge but still uncertain in most places. Diagnostic testing of active and past SARS-CoV-2 infections needs to expand rapidly, ideally using rapid tests. COVID-19 deaths are highly concentrated in the elderly population, with a large proportion of fatalities being "with" rather than "by" SARS-CoV-2 infection. They are often the result of inadequate health care due to overwhelming demands. To date, there is no specific therapy for SARS-CoV-2 infection. Several antivirals are being tested clinically, including remdesivir, at this time the most promising. For others such as lopinavir/ritonavir, neither significant virological nor clinical benefit has been shown. Given the characteristic pulmonary cytokine storm underlying the pathogenic mechanism of severe COVID-19 pneumonia and acute respiratory distress, antiinflammatory agents are being investigated. The benefit of orticosteroids, hydroxychloroquine, etc., is limited. Monoclonal antibodies targeting different pro-inflammatory cytokines, such as tocilizumab, an anti-interleukin 6 agent, are being tried with encouraging results. Ultimately a protective vaccine will be the best response for controlling the COVID-19 pandemic. application/pdf eng Permanyer info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ © Permanyer 2020 Attribution-NonCommercial-NoDerivatives 4.0 Internacional COVID-19 SIDA 2420 Virología COVID-19 comes 40 years after AIDS - any lesson? info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.aidsreviews.com/n.php?any=2020&vol=22&num=2&active=2 SI THUMBNAIL COVID-19-comes-40-years.pdf.jpg COVID-19-comes-40-years.pdf.jpg IM Thumbnail image/jpeg 3738 https://uvadoc.uva.es/bitstream/10324/44140/4/COVID-19-comes-40-years.pdf.jpg bc75a7c114f9f30fabd36601c9a3801b MD5 4 LICENSE license.txt license.txt text/plain 3926 https://uvadoc.uva.es/bitstream/10324/44140/3/license.txt 017313583e37a1e4d1253e1ef6c66c6c MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 817 https://uvadoc.uva.es/bitstream/10324/44140/2/license_rdf 975848b171c53b753f7e445c8b5bc0e1 MD5 2 ORIGINAL COVID-19-comes-40-years.pdf COVID-19-comes-40-years.pdf application/pdf 934764 https://uvadoc.uva.es/bitstream/10324/44140/1/COVID-19-comes-40-years.pdf 078ebc999ac88a3c94b2190c635f1a18 MD5 1 10324/44140 oai:uvadoc.uva.es:10324/44140 2021-06-24 09:25:41.516 UVaDOC repositorio@uva.es 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