2024-03-28T18:19:34Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/59952021-06-23T09:48:14Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
Barrio, Laura del
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Egea, Javier
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León, Rafael
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Romero, Alejandro
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Ruiz, Ana
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Montero Zoccola, María Teresa
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0000-0001-7702-6653
Álvarez Martín, Javier
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0000-0003-0636-5521
López, Manuela G.
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2014-09-16T16:37:02Z
2015-09-16T23:40:10Z
2011
British Journal of Pharmacology, 2011, vol. 162, p. 94-110
0007-1188
http://uvadoc.uva.es/handle/10324/5995
10.1111/j.1476-5381.2010.01034.x
94
110
British Journal of Pharmacology
162
Producción Científica
Ca2+ signalling and exocytosis mediated by nicotinic receptor (nAChR) subtypes, especially the a7 nAChR, in bovine
chromaffin cells are still matters of debate.We have used chromaffin cell cultures loaded with Fluo-4 or transfected with aequorins directed to the cytosol or
mitochondria, several nAChR agonists (nicotine, 5-iodo-A-85380, PNU282987 and choline), and the a7 nAChR allosteric
modulator PNU120596. Minimal [Ca2+]c transients, induced by low concentrations of selective a7 nAChR agonists and nicotine, were markedly
increased by the a7 nAChR allosteric modulator PNU120596. These potentiated responses were completely blocked by the
a7 nAChR antagonist a-bungarotoxin (a7-modulated-response). Conversely, high concentrations of the a7 nAChR agonists,
nicotine or 5-iodo-A-85380 induced larger [Ca2+]c transients, that were blocked by mecamylamine but were unaffected by
a-bungarotoxin (non-a7 response). [Ca2+]c increases mediated by a7 nAChR were related to Ca2+ entry through non-L-type
Ca2+ channels, whereas non-a7 nAChR-mediated signals were related to L-type Ca2+ channels; Ca2+-induced Ca2+-release
contributed to both responses. Mitochondrial involvement in the control of [Ca2+]c transients, mediated by either receptor,
was minimal. Catecholamine release coupled to a7 nAChRs was more efficient in terms of catecholamine released/[Ca2+]c.
2015-09-16
application/pdf
eng
Wiley
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Calcio
Calcium signalling mediated through a7 and non-a7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release
info:eu-repo/semantics/article
SI
THUMBNAIL
ALVAREZ 30- Calcium signalling mediated through a7.pdf.jpg
ALVAREZ 30- Calcium signalling mediated through a7.pdf.jpg
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ALVAREZ 30- Calcium signalling mediated through a7.pdf
ALVAREZ 30- Calcium signalling mediated through a7.pdf
PD-118
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https://uvadoc.uva.es/bitstream/10324/5995/1/ALVAREZ%2030-%20Calcium%20signalling%20mediated%20through%20a7.pdf
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2021-06-23 11:48:14.647
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