2026-07-22T11:07:54Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/616122026-04-09T08:41:25Zcom_10324_1179com_10324_931com_10324_894com_10324_1133col_10324_1306col_10324_1209

Usategui Martín, Ricardo 1460ea1860384eb0 600 Real, Álvaro del 5b0ce75c-28d3-4b2c-b282-fe0b6a338beb 600 Sainz-Aja Guerra, José A. 118a2c9d-2904-4a38-b913-25cd0b0ef9bf Prieto Lloret, Jesús 41215fed9469daa3 600 0000-0002-5281-0211 Olea Fraile, Elena b79dc96e164f4816 600 Rocher Martín, María Asunción 4fa609c495599ebc 600 0000-0001-9043-0474 Rigual Bonastre, Ricardo Jaime ffe0cce4ad32e845 600 Riancho Moral, José Antonio cff8925d-e99d-4964-99a1-346adfd071cd 600 Pérez Castrillon, José Luis 042f614ba966d764 600 2023-09-18T11:54:52Z 2023-09-18T11:54:52Z 2022 International Journal of Molecular Sciences, 2022, Vol. 23, Nº. 21, 12742 1422-0067 https://uvadoc.uva.es/handle/10324/61612 10.3390/ijms232112742 12742 21 International Journal of Molecular Sciences 23 1422-0067 Producción Científica Hypoxia may be associated with alterations in bone remodeling, but the published results are contradictory. The aim of this study was to characterize the bone morphometry changes subject to hypoxia for a better understanding of the bone response to hypoxia and its possible clinical consequences on the bone metabolism. This study analyzed the bone morphometry parameters by micro-computed tomography (μCT) in rat and guinea pig normobaric hypoxia models. Adult male and female Wistar rats were exposed to chronic hypoxia for 7 and 15 days. Additionally, adult male guinea pigs were exposed to chronic hypoxia for 15 days. The results showed that rats exposed to chronic constant and intermittent hypoxic conditions had a worse trabecular and cortical bone health than control rats (under a normoxic condition). Rats under chronic constant hypoxia were associated with a more deteriorated cortical tibia thickness, trabecular femur and tibia bone volume over the total volume (BV/TV), tibia trabecular number (Tb.N), and trabecular femur and tibia bone mineral density (BMD). In the case of chronic intermittent hypoxia, rats subjected to intermittent hypoxia had a lower cortical femur tissue mineral density (TMD), lower trabecular tibia BV/TV, and lower trabecular thickness (Tb.Th) of the tibia and lower tibia Tb.N. The results also showed that obese rats under a hypoxic condition had worse values for the femur and tibia BV/TV, tibia trabecular separation (Tb.Sp), femur and tibia Tb.N, and BMD for the femur and tibia than normoweight rats under a hypoxic condition. In conclusion, hypoxia and obesity may modify bone remodeling, and thus bone microarchitecture, and they might lead to reductions in the bone strength and therefore increase the risk of fragility fracture. Ministerio de Economía y Competitividad y Fondo Europeo de Desarrollo Regional (FEDER) - (project BFU2015-70616-R) Junta de Castilla y León, Consejería de Educación - (Grant CCVC8485) application/pdf eng MDPI info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2022 The Authors Atribución 4.0 Internacional Hypoxia Hipoxia Biometry Biometría Bone remodeling Huesos - Regeneración Bone - Diseases Huesos - Enfermedades - Diagnóstico Obesity Obesidad Tomography Tomografía computada Animal Models Modelos animales Laboratory animals Animales de laboratorio Animal experimentation Experimentación animal 2415 Biología Molecular 3201.04 Patología Clínica Analysis of bone histomorphometry in rat and guinea pig animal models subject to hypoxia info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.mdpi.com/1422-0067/23/21/12742 SI THUMBNAIL Analysis-of-Bone-Histomorphometry.pdf.jpg Analysis-of-Bone-Histomorphometry.pdf.jpg IM Thumbnail image/jpeg 3466 https://uvadoc.uva.es/bitstream/10324/61612/4/Analysis-of-Bone-Histomorphometry.pdf.jpg f9d3ed722d95681713409c690cbd6470 MD5 4 LICENSE license.txt license.txt text/plain 3929 https://uvadoc.uva.es/bitstream/10324/61612/3/license.txt 289d98c1665ee0d20312360f0e8643c8 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 921 https://uvadoc.uva.es/bitstream/10324/61612/2/license_rdf 9eecc1514e7247cad41e4db756248760 MD5 2 ORIGINAL Analysis-of-Bone-Histomorphometry.pdf Analysis-of-Bone-Histomorphometry.pdf application/pdf 1444449 https://uvadoc.uva.es/bitstream/10324/61612/1/Analysis-of-Bone-Histomorphometry.pdf 44c0b8421e541a1230d5ab35efe614aa MD5 1 10324/61612 oai:uvadoc.uva.es:10324/61612 2026-04-09 10:41:25.405 UVaDOC repositorio@uva.es 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