2026-05-16T06:02:05Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/638292025-01-22T09:07:14Zcom_10324_1181com_10324_931com_10324_894col_10324_1387

Díez Revuelta, Álvaro 7c1727d2a6a9a098 600 Gómez Pilar, Javier 2a0c86ec61379bf6 600 0000-0001-7882-7890 Poza Crespo, Jesús c33645a6dc1b0f93 600 0000-0001-8577-9559 Beño Ruiz De La Sierra, Rosa María 4c41611f79416427 600 Fernández Linsenbarth, Ines eb0df380de66c2d2 600 Recio Barbero, María 2d166c8b-e4d3-4f78-be40-23d1626befd8 600 Núñez Novo, Pablo 74f4ef60f09d334c 600 Holgado Madera, Pedro 49cb4b6f-d409-4564-962d-2c05dcafae20 600 Molina Rodríguez, Vicente 5283563a4ecd618a 600 0000-0003-2457-2487 2023-12-23T16:54:05Z 2023-12-23T16:54:05Z 2024 Progress in Neuropsychopharmacology & Biological Psychiatry 129 (2024) 110902 0278-5846 https://uvadoc.uva.es/handle/10324/63829 10.1016/j.pnpbp.2023.110902 110902 Progress in Neuro-Psychopharmacology and Biological Psychiatry 129 Background: The study of the cortical functional network properties in schizophrenia (SZ) may benefit from the use of graph theory parameters applied to high-density electroencephalography (EEG). Connectivity Strength (CS) assesses global synchrony of the network, and Shannon Graph Complexity (SGC) summarizes the network distribution of link weights and allows distinguishing between primary and secondary pathways. Their joint use may help in understanding the underpinnings of the functional network hyperactivation and task-related hypomodulation previously described in psychoses. Methods: We used 64-sensor EEG recordings during a P300 oddball task in 128 SZ patients (96 chronic, CR, and 32 first episodes, FE), as well as 46 bipolar disorder (BD) patients, and 92 healthy controls (HC). Pre-stimulus and modulation (task-response minus pre-stimulus windows values) of CS and SGC were assessed in the theta band (4–8 Hz) and the broadband (4–70 Hz). Results: Compared to HC, SZ patients (CR and FE) showed significantly higher pre-stimulus CS values in the broadband, and both SZ and BD patients showed lower theta-band CS modulation. SGC modulation values, both theta-band and broadband, were also abnormally reduced in CR patients. Statistically significant relationships were found in the theta band between SGC modulation and both CS pre-stimulus and modulation values in patients. CS altered measures in patients were additionally related to their cognitive outcome and negative symptoms. A primary role of antipsychotics in these results was ruled out. Conclusions: Our results linking SGC and CS alterations in psychotic patients supported a hyperactive and hypomodulatory network mainly involving connections in secondary pathways. application/pdf spa info:eu-repo/semantics/openAccess Functional network properties in schizophrenia and bipolar disorder assessed with high-density electroencephalography info:eu-repo/semantics/article info:eu-repo/semantics/draft SI THUMBNAIL 2024_Diez_funct_ntwrk_ properties_sch+bip_high-density_eeg.pdf.jpg 2024_Diez_funct_ntwrk_ properties_sch+bip_high-density_eeg.pdf.jpg IM Thumbnail image/jpeg 2261 https://uvadoc.uva.es/bitstream/10324/63829/3/2024_Diez_funct_ntwrk_%20properties_sch%2bbip_high-density_eeg.pdf.jpg 099d5dbf91450f9ee3a8cdef06c007f5 MD5 3 LICENSE license.txt license.txt text/plain 3929 https://uvadoc.uva.es/bitstream/10324/63829/2/license.txt 289d98c1665ee0d20312360f0e8643c8 MD5 2 ORIGINAL 2024_Diez_funct_ntwrk_ properties_sch+bip_high-density_eeg.pdf 2024_Diez_funct_ntwrk_ properties_sch+bip_high-density_eeg.pdf artículo application/pdf 5723577 https://uvadoc.uva.es/bitstream/10324/63829/1/2024_Diez_funct_ntwrk_%20properties_sch%2bbip_high-density_eeg.pdf 99c389fe6b9c7b283be808e0c37e6a65 MD5 1 10324/63829 oai:uvadoc.uva.es:10324/63829 2025-01-22 10:07:14.941 UVaDOC repositorio@uva.es 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