2026-07-16T14:43:46Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/703002025-01-21T08:17:19Zcom_10324_1138com_10324_931com_10324_894col_10324_1226
Medina Polo, José
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Falkensammer, Eva
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Köves, Béla
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Kranz, Jennifer
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Tandogdu, Zafer
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Tapia Herrero, Ana María
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600
0000-0001-5556-7504
Cai, Tommaso
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Wagenlehner, Florian M. E.
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Schneidewind, Laila
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Bjerklund Johansen, Truls Erik
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2024-10-02T08:03:41Z
2024-10-02T08:03:41Z
2024
Antibiotics, 2024, Vol. 13, Nº. 5, 442
2079-6382
https://uvadoc.uva.es/handle/10324/70300
10.3390/antibiotics13050442
442
5
Antibiotics
13
2079-6382
Producción Científica
(1) Background: Urinary tract infections (UTIs) are among the most frequent complications in kidney transplant (KT) recipients. Asymptomatic bacteriuria (ASB) may be a risk factor for UTIs and graft rejection. We aimed to evaluate available evidence regarding the benefit of screening and treatment of ASB within the first year after KT. (2) Evidence acquisition: A systematic literature search was conducted in MEDLINE, the Cochrane Library CENTRAL and Embase. Inclusion criteria were manuscripts in English addressing the management of ASB after KT. The PICO questions concerned Patients (adults receiving a KT), Intervention (screening, diagnosis and treatment of ASB), Control (screening and no antibiotic treatment) and Outcome (UTIs, sepsis, kidney failure and death). (3) Evidence synthesis: The systematic review identified 151 studies, and 16 full-text articles were evaluated. Seven were excluded because they did not evaluate the effect of treatment of ASB. There was no evidence for a higher incidence of lower UTIs, acute pyelonephritis, graft loss, or mortality in patients not treated with antibiotics for ASB. Analysis of comparative non-randomized and observational studies did not provide supplementary evidence to guide clinical recommendations. We believe this lack of evidence is due to confounding risk factors that are not being considered in the stratification of study patients.
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eng
MDPI
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2024 The authors
Atribución 4.0 Internacional
Antibiotics
Antibióticos
Urologic diseases
Urinario, Aparato - Enfermedades - Tratamiento
Urology
Nephrology
Kidneys - Diseases
Riñones - Enfermedades
Kidneys - Transplantation
Riñones - Trasplante
Urinary tract infections
Vías urinarias - Infecciones
Insuficiencia renal aguda
Acute renal failure
Meta-analysis
Systematic reviews (Medical research)
Medicina - Investigación
Public health
3213.16 Urología
3205.06 Nefrología
32 Ciencias Médicas
3212 Salud Publica
Systematic review and meta-analysis provide no guidance on management of asymptomatic bacteriuria within the first year after kidney transplantation
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://www.mdpi.com/2079-6382/13/5/442
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Systematic-Review-and-Meta-Analysis.pdf
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2025-01-21 09:17:19.998
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