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oai:uvadoc.uva.es:10324/756132026-02-19T21:00:55Zcom_10324_40357com_10324_952com_10324_894col_10324_40359

Nieto Miguel, Teresa 8c92d5c7000865cc 600 Galindo de la Rosa, Sara a775d667e4464c4d 600 0000-0002-3184-2425 López Paniagua, Marina 44f714e9c8edc2eb 600 0000-0002-5712-3322 Pérez Soto, María Inmaculada 7cb78eb54675c667 600 Herreras Cantalapiedra, José María 9835eba3ed760121 600 0000-0001-5487-0579 Calonge, Margarita 84265c5c562482d4 600 0000-0001-8178-4836 2025-04-17T11:40:25Z 2025-04-17T11:40:25Z 2019 Nieto-Miguel, T., Galindo, S., López-Paniagua, M., Pérez, I., Herreras, J.M., Calonge, M. Cell Therapy Using Extraocular Mesenchymal Stem Cells. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. Nieto-Miguel, T., Galindo, S., López-Paniagua, M., Pérez, I., Herreras, J.M., Calonge, M. (2019). Cell Therapy Using Extraocular Mesenchymal Stem Cells. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. 2019, p. 231-262 . 978-3-030-01304-2 978-3-030-01303-5 https://uvadoc.uva.es/handle/10324/75613 231 262 Corneal Regeneration. Therapy and Surgery. Producción Científica Extraocular mesenchymal stem cells (MSCs) represent an available, non-immunogenic source of stem cells that has proved to possess a potential therapeutic value in corneal epithelium regeneration based on results obtained in both preclinical and clinical studies. All published studies have revealed promising results in animal models and have shown significant corneal regeneration, improved corneal transparency and a rapid healing process associated with the restoration of vision. However, the studies performed to unravel the mechanisms underlying the beneficial effects of MSCs on the damaged ocular surface have shown that multiple mechanisms might contribute simultaneously to their therapeutic action. Although it remains uncertain if MSCs can transdifferentiate into corneal epithelial cells, these cells have shown a capacity of secreting trophic and growth factors capable of stimulating resident stem cells and reducing tissue injury, an ability to exert anti-inflammatory and immunomodulatory effects, and a capability to migrate into injured tissues. This book chapter is specifically focused on the preclinical and clinical advancements on the use of extraocular MSCs for corneal epithelium regeneration. Ministerio de Economía y Competitividad y el Fondo Europeo de Desarrollo Regional, España (subvención SAF2015-63594-R MINECO/FEDER, UE) Instituto Nacional de Salud Carlos III, CIBER-BBN (CB06/01/003 MICINN/FEDER, UE) application/pdf eng Springer Nature info:eu-repo/semantics/openAccess Copyright © 2019, Springer Nature Switzerland AG Cornea Ocular surface Cell therapy Mesenchymal stem cells Regeneration 2410 Biología Humana 2407 Biología Celular 3201.09 Oftalmología Cell therapy using extraocular cells: mesenchymal stem cells info:eu-repo/semantics/bookPart info:eu-repo/semantics/accepttedVersion https://doi.org/10.1007/978-3-030-01304-2_17 ORIGINAL Portada-indice-Corneal-Regeneration-Therapy-and-Surgery.pdf Portada-indice-Corneal-Regeneration-Therapy-and-Surgery.pdf application/pdf 510212 https://uvadoc.uva.es/bitstream/10324/75613/5/Portada-indice-Corneal-Regeneration-Therapy-and-Surgery.pdf 454c5d2d81f4109e9f29e39bb7ea061d MD5 5 Cell-therapy-using-extraocular-cells-mesenchymal-stem-cells.pdf Cell-therapy-using-extraocular-cells-mesenchymal-stem-cells.pdf application/pdf 1005526 https://uvadoc.uva.es/bitstream/10324/75613/6/Cell-therapy-using-extraocular-cells-mesenchymal-stem-cells.pdf c6225ec7a4fe568591b2ce82349a3feb MD5 6 THUMBNAIL 2019 Nieto-Miguel et al. Springer Nature book chapter_Cell therapy using extraocular mesenchymal stem cells.pdf.jpg 2019 Nieto-Miguel et al. 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