2026-03-16T17:48:48Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/833152026-03-03T20:01:15Zcom_10324_1181com_10324_931com_10324_894col_10324_1387

Osorio Iriarte, María Emma 42878d4ef01f6d40 600 0009-0003-9237-5351 Díez Revuelta, Álvaro 7c1727d2a6a9a098 600 Fernández Linsenbarth, Ines eb0df380de66c2d2 600 Arjona Valladares, Antonio 1eaeac54f7c3a1c1 600 Beño Ruiz De La Sierra, Rosa María 4c41611f79416427 600 Roig Herrero, Alejandro dcb22731925a5546 600 0000-0002-5167-5214 Martínez Sánchez, José María 347d43df-85a4-41e1-9bf1-9aef45a67d29 Sobrino Conde, Luis 1c445c1e-bbbc-418f-82b7-d1ec7aa86ce2 Molina Rodríguez, Vicente 5283563a4ecd618a 600 0000-0003-2457-2487 2026-03-03T12:22:19Z 2026-03-03T12:22:19Z 2026 Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2026, vol. 145, p. 111646 0278-5846 https://uvadoc.uva.es/handle/10324/83315 10.1016/j.pnpbp.2026.111646 111646 Progress in Neuro-Psychopharmacology and Biological Psychiatry 145 Producción Científica Background and hypothesis: Schizophrenia and other psychotic disorders exhibit significant clinical and cognitive heterogeneity, challenging diagnosis and treatment. Given indications of widespread cortical hyperactivity and dysregulation of neural oscillations in schizophrenia, investigating resting-state activity is highly relevant. This study examined resting-state EEG alterations across previously defined cognitive subtypes within the psychosis spectrum. Study design: We analyzed resting-state EEG data from 141 psychosis patients (64 chronic schizophrenia, 40 first- episode schizophrenia, 37 bipolar disorder) and 80 healthy controls. Patients were a priori classified into two distinct cognitive subgroups: Cluster 1 (severe impairment, n = 47) and Cluster 2 (moderate impairment, n = 94). Study results: Both patient clusters exhibited increased spectral power across most frequency bands compared to healthy controls. Notably, the more severely impaired Cluster 1 showed significantly higher power in the gamma-1 band (30–45 Hz) compared to Cluster 2. Furthermore, in Cluster 1, a significant positive correlation was found between resting-state gamma-1 power and positive symptom scores. Conclusions: These results support our hypothesis of distinctive basal hyperactivation linked to the cognitive profile, suggesting that altered intrinsic brain activity, particularly gamma-1 hyperactivation, may underlie cognitive heterogeneity in psychosis. This also suggests that gamma-1 band hyperactivation at rest serves as a distinct neurophysiological marker differentiating both subgroups. Our findings highlight the importance of subdivision approaches to identify more homogeneous patient subgroups and emphasize the potential of resting- state gamma activity as a precise biomarker for specific symptom dimensions and personalized treatment strategies. Instituto de Salud Carlos III (ID PI22/00465) Junta de Castilla y León - Gerencia Regional de Salud de Castilla y León (GRS-2487/A/22 y GRS-2685/A1/2023) Fundación La Marató (ID 571/C/2022) Junta de Castilla y León (Consejería de Educación) y el Fondo Social Europeo (ID VA-229-23 a la EOI) Ministerio de Ciencia e Innovación - Agencia Estatal de Investigación (PRE2022–104038) application/pdf eng Elsevier info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2026 The Author(s) Atribución 4.0 Internacional Electroencephalography Resting-state EEG Gamma band Schizophrenia Biomarker 3211 Psiquiatría Resting-state gamma activity as a discriminative marker for cognitive subtypes in psychosis info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0278584626000424 SI THUMBNAIL Resting-state-gamma-activity-discriminative.pdf.jpg Resting-state-gamma-activity-discriminative.pdf.jpg IM Thumbnail image/jpeg 2390 https://uvadoc.uva.es/bitstream/10324/83315/4/Resting-state-gamma-activity-discriminative.pdf.jpg 5b697bd5d891f3356ac281d978079cf7 MD5 4 LICENSE license.txt license.txt text/plain 3929 https://uvadoc.uva.es/bitstream/10324/83315/3/license.txt 289d98c1665ee0d20312360f0e8643c8 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 921 https://uvadoc.uva.es/bitstream/10324/83315/2/license_rdf 9eecc1514e7247cad41e4db756248760 MD5 2 ORIGINAL Resting-state-gamma-activity-discriminative.pdf Resting-state-gamma-activity-discriminative.pdf application/pdf 2669966 https://uvadoc.uva.es/bitstream/10324/83315/1/Resting-state-gamma-activity-discriminative.pdf 4c4936ed5080ab07de8e4327ac3a6aef MD5 1 10324/83315 oai:uvadoc.uva.es:10324/83315 2026-03-03 21:01:15.521 UVaDOC repositorio@uva.es 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