RT info:eu-repo/semantics/article
T1 CD148, a membrane protein tyrosine phosphatase, is able to induce tyrosine phosphorylation on human lymphocytes
A1 Palou, Eduard
A1 Fuente García, Miguel Ángel de la
A1 Nicolás, Josep Maria
A1 Vilardell, Carme
A1 Vives, Jordi
A1 Gayá, Antoni
K1 Células hematopoyéticas
K1 Hematología
AB CD148 is a new cluster of differentiation defined in the VI International Workshop on Leucocyte Differentiation Antigens. It has been identified as the hematopoietic form of a formerly described membrane protein tyrosine phosphatase called HPTP eta/ DEP-1. Previous data have demonstrated that this molecule is able to give rise to [Ca2+]i increase. In the present work we show its capability to induce protein tyrosine phosphorylation in human lymphocytes in spite of its intrinsic protein tyrosine phosphatase activity. The induction of kinase activity suggests the involvement of some protein tyrosine kinase based signaling pathway. The activation of this postulated kinase could be carried out through a direct association or via an adapter molecule.
PB Elsevier
SN 0165-2478
YR 1997
FD 1997
LK http://uvadoc.uva.es/handle/10324/10380
UL http://uvadoc.uva.es/handle/10324/10380
LA eng
NO Immunology Letters, 1997, 57(1-3):101-103
NO Producción Científica
DS UVaDOC
RD 22-nov-2024