RT info:eu-repo/semantics/masterThesis
T1 Synthesis and characterization of  amphiphilic elastin-like recombinamers: Development of self-assembling  nanoparticles and hydrogels
A1 Acosta Rodríguez, Sergio
A2 Universidad de Valladolid. Facultad de Ciencias
K1 Nanotecnología - Aplicaciones en Medicina
AB Nanotechnology is one of the science fields with a great development in the lastyears, with an imperative necessity to produce systems with specific functionalities atnanometric scale. Nanotechnology has provided sophisticated tools that haverevolutionized many areas of knowledge, such as biomedical science, where enablesimproving efficiency and accuracy of current diagnostic techniques, and developing saferand more effective therapeutics1.In many cases, these systems are inspired by nature, trying to mimic nanometricstructures formed by proteins and or other macromolecules in the living tissues and cells.Elastin-Like-Recombinamers (ELRs) are excellent candidates to develop systems thatmimic the extracellular matrix structure due to their smart behavior and their recombinantnature. And they could be applied for instance, to develop treatments for connective tissuediseases as arthrosis.The recombinant nature is one of the most important features of these polymers,that allows to produce them by recombinant expression in Escherichia coli from predesignedgenes. So we are able to design new materials with enormous potential thatintegrate new properties incorporated by genetic engineering for specific applications innanomedicine.The study shown here is focused on the development of new systems intendedfor injectable hydrogels in regenerative medicine, and for spherical nanocarriers in drugdelivery. Based on the ability of self-organization into nanostructures demonstrated byprevious amphiphilic tetrablock ELR2, three new copolymers have been developed varyingthe individual blocks size, of the original tetrablock ELR. Thus, the aim of thisinvestigation is to shed light about the influence of the block sizes on the physicochemicalproperties and on the structuration of the nanoparticles and of the hydrogels, with the finalgoal of setting the basis to perform a rational design from the sequence level.
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/13620
UL http://uvadoc.uva.es/handle/10324/13620
LA eng
NO Departamento de Física de la Materia Condensada, Cristalografía y Mineralogía
DS UVaDOC
RD 22-nov-2024