RT info:eu-repo/semantics/article
T1 Toll-Like receptor 2 R753Q polymorphisms are associated with an increased risk of infective endocarditis
A1 Bustamante Munguira, Juan
A1 Tamayo Gómez, Eduardo
A1 Flórez, Santiago
A1 Tellería Orriols, Juan José
A1 Bustamante Munguira, Elena
A1 López Díaz, Javier
A1 San Román Calvar, José Alberto
A1 Álvarez González, Francisco Javier
K1 Endocarditis
AB The ability to respond to the ligands of toll-like receptors (TLR) could be affected by single nucleotidepolymorphisms in TLR codifying genes. The influence of the polymorphisms TLR2 (R753Q, R677W), TLR4(D299G, T399I) and CD14 (C-159T) was consecutively studied in 65 patients with infective endocarditis.The control group (n=66) consisted of healthy volunteers. All the polymorphisms were genotyped bymeans of restriction analysis after their amplification. An association between endocarditis and variantsof TLR2 R753Q (P < .001) was observed, but no association with other polymorphisms was found.The TLR2 R753Q co-dominant (odds ratio=13.33), recessive (odds ratio=9.12) and dominant(odds ratio=3.65) genotypes showed a positive association with the infective endocarditis phenotype.The polymorphism TLR2 R753Q was associated with a greater susceptibility towards the development ofinfective endocarditis. Further studies are required to validate these results and identify other geneticrisk factors.
PB Elsevier
SN 1885-5857
YR 2011
FD 2011
LK http://uvadoc.uva.es/handle/10324/15414
UL http://uvadoc.uva.es/handle/10324/15414
LA eng
NO Revista Española de Cardiología, 2011;64(11):1056–1059
NO Producción Científica
DS UVaDOC
RD 22-nov-2024