RT info:eu-repo/semantics/article
T1 Ventilator-associated pneumonia is an important risk factor for mortality after major cardiac surgery
A1 Tamayo Gómez, Eduardo
A1 Álvarez González, Francisco Javier
A1 Martínez Rafael, Beatriz
A1 Bustamante Munguira, Juan
A1 Bermejo Martín, Jesús Francisco
A1 Fierro Lorenzo, María Inmaculada
A1 Eiros Bouza, José María
K1 Cardiovascular, Aparato - Cirugía - Complicaciones y secuelas
K1 Neumonía
AB Ventilator-associated pneumonia (VAP) is the main infectious complication in cardiac surgery patients and is associated with an important increase in morbidity and mortality. The aim of our study was to analyze the impact of VAP on mortality excluding other comorbidities and to study its etiology and the risk factors for its development. MATERIALS AND METHODS: This prospective cohort study included 1610 postoperative cardiac surgery patients' status post cardiopulmonary bypass (CPB) between July 2004 and January 2008. The primary outcome measures were the development of VAP and in-hospital mortality. RESULTS: Ventilator-associated pneumonia was observed in 124 patients (7.7%). Patients with VAP had a longer length of hospitalization (40.7 ± 35.1 vs 16.1 ± 30.1 days, P <.0001) and greater in-hospital mortality (49.2% [61/124] vs 2.0% [30/1486], P =.0001) in comparison with patients without VAP. After performing the Cox multivariant analysis adjustment, VAP was identified as the most important independent mortality risk factor (adjusted hazard ratio [HR], 8.53; 95% confidence interval, 4.21-17.30; P =.0001). Other independent risk factors of in-hospital mortality were chronic renal failure (HR, 2.56), diabetes mellitus (HR, 1.90), CPB time (HR, 1.51), respiratory failure (HR, 2.13), acute renal failure (HR, 2.39), and mediastinal bleeding of at least 1000 mL (HR, 1.81).
PB Elsevier
SN 0883-944
YR 2012
FD 2012
LK http://uvadoc.uva.es/handle/10324/15415
UL http://uvadoc.uva.es/handle/10324/15415
LA eng
NO Journal of Critical Care, (2012);27(1):18-25
NO Producción Científica
DS UVaDOC
RD 22-dic-2024