RT info:eu-repo/semantics/article
T1 Comparative study of single-dose and 24-hour multiple-dose antibiotic prophylaxis for cardiac surgery
A1 Tamayo Gómez, Eduardo
A1 Gualis, Javier
A1 Flórez, Santiago
A1 Castrodeza Sanz, José Javier
A1 Eiros Bouza, José María
A1 Álvarez González, Francisco Javier
K1 Cardiovascular, Aparato - Cirugía - Infecciones
AB Use of single-dose antibiotic prophylaxis is associated with reduced antibiotic resistance, lower costs,and fewer problems with drug toxicity and superinfections. We tested the hypothesis that single doses of cefazolinare as effective as a 24-hour regimen of cefazolin in preventing surgical site infections in adults undergoing cardiacprocedures. This random, prospective, clinical study included 838 adult patients undergoing elective coronary arterybypass grafting, valve operations, or both. These patients were randomly given a single dose of cefazolin (2 g)or a 24-hour treatment (2-g initial dose, followed by 1 g every 8 hours). Investigators blinded to the drug regimendiagnosed wound infections according to Centers for Disease Control and Prevention criteria. Patient clinical anddemographic characteristics were noted, with follow-up for 12 postoperative months. The primary objective wasto compare the incidence of surgical infections between groups up to 12 months postoperatively.Results: A total of 419 patients received single-dose cefazolin, and another 419 received the 24-hour treatment.Surgical site infection occurred in 35 (8.3%) patients receiving single doses and 15 (3.6%) patients administeredthe 24-hour treatment (P ¼ .004). We identified no differences between groups for mortality or duration of hospitalization(preoperative hospitalization, intensive care unit stay, and hospitalization after surgical intervention).The microorganisms isolated showed a similar distribution in both groups. The germs isolated were gram-positivecocci in 86% of the surgical site infections. Single-dose cefazolin used as antibiotic prophylaxis in cardiac surgery is associated with a highersurgical site infection rate than the 24-hour, multiple-dose cefazolin regimen.
PB Elsevier
SN 0022-5223
YR 2008
FD 2008
LK http://uvadoc.uva.es/handle/10324/15619
UL http://uvadoc.uva.es/handle/10324/15619
LA eng
NO The Journal of Thoracic and Cardiovascular Surgery, 2008; 136( 6 ): 1522-1527
NO Producción Científica
DS UVaDOC
RD 26-abr-2024