RT info:eu-repo/semantics/article
T1 Organocatalytic Domino Michael-Heterocyclization Reaction of Unsaturated Aldehydes and Cyano Ketones. Synthesis of Enantioenriched 4,5,6-Trisubstituted 3,4-Dihydropyranones
A1 Guevara Pulido, James Oswaldo
A1 Andrés García, José María
A1 Pedrosa Sáez, Rafael
K1 Química orgánica
AB α,β-Unsaturated aldehydes with aliphatic, electron-poor aromatic, or electron-withdrawing substituents at the β position easily react with different ketones leading to enantioenriched hemiacetals, which were further oxidized to give 4,5,6-trisubstituted-3,4-dihydropyranones in good yields and with excellent enantioselectivities. The behavior of the ketones is dependent on the α substituent of the carbonyl group, and a fine-tuning of the pKa values is necessary to obtain good results.
PB Wiley
SN 1434-193X
YR 2014
FD 2014
LK http://uvadoc.uva.es/handle/10324/21446
UL http://uvadoc.uva.es/handle/10324/21446
LA eng
NO European Journal of Organic Chemistry, 2014, Volume 2014, Issue 36, p. 8072–8076
NO Producción Científica
DS UVaDOC
RD 22-nov-2024