RT info:eu-repo/semantics/article
T1 One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones
A1 Guevara Pulido, James Oswaldo
A1 Andrés García, José María
A1 Pedrosa Sáez, Rafael
K1 Catalizadores
K1 Química orgánica
AB Enantioenriched trisubstituted lactones were obtained in good yields and moderate to very good enantioselectivities in one-pot process, which implies a sequential organocatalyzed Michael addition of ketones to enals, followed by catalytic intramolecular diastereoselective Tishchenko reaction and lactonization. The final lactones were obtained as single diastereoisomers, demonstrating that the mixture of the anti and syn diastereomers epimerized to the syn hydroxy ester during the oxido-reduction step.
PB American Chemical Society
SN 0022-3263
YR 2014
FD 2014
LK http://uvadoc.uva.es/handle/10324/21448
UL http://uvadoc.uva.es/handle/10324/21448
LA eng
NO Journal of Organic Chemistry, 2014, 79(18), p. 8638-8644
NO Producción Científica
DS UVaDOC
RD 28-nov-2024