RT info:eu-repo/semantics/article
T1 MEG Analysis of Neural Interactions in Attention-Deficit/Hyperactivity Disorder
A1 Khadmaoui, Amine
A1 Gómez Peña, Carlos
A1 Poza Crespo, Jesús
A1 Bachiller Matarranz, Alejandro
A1 Fernández, Alberto
A1 Quintero, Javier
A1 Hornero Sánchez, Roberto
K1 Neural Interactions
AB The aim of the present study was to explore the interchannel relationships of resting-state brain activity in patients with attentiondeficit/hyperactivity disorder (ADHD), one of the most common mental disorders that develop in children. Magnetoencephalographic (MEG) signals were recorded using a 148-channel whole-head magnetometer in 13 patients with ADHD (range: 8–12 years) and 14 control subjects (range: 8–13 years).Three complementary measures (coherence, phase-locking value, and Euclidean distance) were calculated in the conventionalMEG frequency bands: delta, theta, alpha, beta, and gamma. Our results showed that the interactions among MEG channels are higher for ADHD patients than for control subjects in all frequency bands. Statistically significant differences were observed for short-distance values within right-anterior and central regions, especially at delta, beta,and gamma-frequency bands (𝑝 < 0.05; Mann-Whitney 𝑈 test with false discovery rate correction). These frequency bands also showed statistically significant differences in long-distance interactions, mainly among anterior and central regions, as well as among anterior, central, and other areas. These differences might reflect alterations during brain development in children with ADHD. Our results support the role of frontal abnormalities in ADHD pathophysiology, which may reflect a delay in cortical maturation in the frontal cortex.
PB Hindawi Publishing Corporation
SN 1687-5265
YR 2016
FD 2016
LK http://uvadoc.uva.es/handle/10324/21559
UL http://uvadoc.uva.es/handle/10324/21559
LA eng
NO Computational Intelligence and Neuroscience, Volume 2016, Article ID 8450241, 10 pages
NO Producción Científica
DS UVaDOC
RD 27-dic-2024