RT info:eu-repo/semantics/article T1 Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach A1 Bachiller Matarranz, Alejandro A1 Romero, Sergio A1 Molina Rodríguez, Vicente A1 Alonso, Joan F. A1 Mañanas, Miguel A. A1 Poza Crespo, Jesús A1 Hornero Sánchez, Roberto K1 Schizophrenia AB The present study investigates the neural substrates underlying cognitive processing in schizophrenia (Sz) patients. To this end, an auditory 3-stimulus oddball paradigm was used to identify P3a and P3b components, elicited by rare-distractor and rare-target tones, respectively. Event-related potentials (ERP) were recorded from 31 Sz patients and 38 healthy controls. The P3a and P3b brain-source generators were identified by timeaveragingof low-resolution brain electromagnetic tomography (LORETA) current density images. In contrast with the commonly used fixed window of interest (WOI), we proposed to apply an adaptive WOI, which takes into account subjects' P300 latency variability. Our results showed different P3a and P3b source activation patterns in both groups. P3b sources included frontal, parietal and limbic lobes,whereas P3a response generators were localized over bilateral frontal and superior temporal regions. These areas have been related to the discrimination of auditory stimulus and to the inhibition (P3a) or the initiation (P3b) of motor response in acognitive task. In addition, differences in source localization between Sz and control groups were observed. Sz patients showed lower P3b source activity in bilateral frontal structures and the cingulate. P3a generators were less widespread for Sz patients than for controls in right superior, medial and middle frontal gyrus. Our findings suggest that target and distractor processing involves distinct attentional subsystems, both being altered in Sz. Hence, the study of neuroelectric brain information can provide further insights to understand cognitiveprocesses and underlying mechanisms in Sz. PB Elsevier SN 0920-9964 YR 2015 FD 2015 LK http://uvadoc.uva.es/handle/10324/21593 UL http://uvadoc.uva.es/handle/10324/21593 LA eng NO Schizophrenia Research, 2015, vol. 169, p. 318–325 NO Producción Científica DS UVaDOC RD 29-mar-2024