RT info:eu-repo/semantics/article
T1 Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach
A1 Bachiller Matarranz, Alejandro
A1 Romero, Sergio
A1 Molina Rodríguez, Vicente
A1 Alonso, Joan F.
A1 Mañanas, Miguel A.
A1 Poza Crespo, Jesús
A1 Hornero Sánchez, Roberto
K1 Schizophrenia
AB The present study investigates the neural substrates underlying cognitive processing in schizophrenia (Sz) patients. To this end, an auditory 3-stimulus oddball paradigm was used to identify P3a and P3b components, elicited by rare-distractor and rare-target tones, respectively. Event-related potentials (ERP) were recorded from 31 Sz patients and 38 healthy controls. The P3a and P3b brain-source generators were identified by timeaveragingof low-resolution brain electromagnetic tomography (LORETA) current density images. In contrast with the commonly used fixed window of interest (WOI), we proposed to apply an adaptive WOI, which takes into account subjects' P300 latency variability. Our results showed different P3a and P3b source activation patterns in both groups. P3b sources included frontal, parietal and limbic lobes,whereas P3a response generators were localized over bilateral frontal and superior temporal regions. These areas have been related to the discrimination of auditory stimulus and to the inhibition (P3a) or the initiation (P3b) of motor response in acognitive task. In addition, differences in source localization between Sz and control groups were observed. Sz patients showed lower P3b source activity in bilateral frontal structures and the cingulate. P3a generators were less widespread for Sz patients than for controls in right superior, medial and middle frontal gyrus. Our findings suggest that target and distractor processing involves distinct attentional subsystems, both being altered in Sz. Hence, the study of neuroelectric brain information can provide further insights to understand cognitiveprocesses and underlying mechanisms in Sz.
PB Elsevier
SN 0920-9964
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/21593
UL http://uvadoc.uva.es/handle/10324/21593
LA eng
NO Schizophrenia Research, 2015, vol. 169, p. 318–325
NO Producción Científica
DS UVaDOC
RD 25-nov-2024