RT info:eu-repo/semantics/article
T1 Production of stabilized quercetin aqueous suspensions bysupercritical fluid extraction of emulsions
A1 Lévai, György
A1 Martín Martínez, Ángel
A1 Paz Barragán, Esther de
A1 Rodríguez Rojo, Soraya
A1 Cocero Alonso, María José
K1 Encapsulación
AB Quercetin is a flavonoid with highly promising bioactivity against a variety of diseases, due to its strong antioxidant, antiviral and antihistaminic effect, but these applications are limited by the low solubility of quercetin in gastrointestinal fluids and the correspondingly low bioavailability. The objective of this work is to produce encapsulated quercetin particles in sub-micrometric scale, in order to increase their low bioavailability. These particles were produced by extraction of organic solvent from oil in water emulsions by Supercritical Fluid Extraction of Emulsions (SFEE). Due to the rapid extraction of organic solvent by this method, the disperse organic phase becomes rapidly supersaturated, causing the precipitation of quercetin particles in sub-micrometric scale, encapsulated by the surfactant material. Two different biopolymers (Pluronic L64 ® poloxamers and soy bean lecithin) were used as carriers and surfactant materials. In experiments with Pluronic, needle quercetin particles were obtained after SFEE treatment, with particle sizes around 1 μm and poor encapsulation efficiency. In case of soy lecithin, quercetin-loaded multivesicular liposomes were obtained, with a mean particle size around 100 nm and around 70% encapsulation efficiency of quercetin, without presence of segregated quercetin crystals
PB Elsevier
SN 0896-8446
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/21599
UL http://uvadoc.uva.es/handle/10324/21599
LA eng
NO The Journal of Supercritical Fluids,  2015, vol. 100,  p. 34–45
NO Producción Científica
DS UVaDOC
RD 23-nov-2024