RT info:eu-repo/semantics/article
T1 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
A1 Vila, Mercedes
A1 García, Ana
A1 Girotti, Alessandra
A1 Alonso Rodrigo, Matilde
A1 Rodríguez Cabello, José Carlos
A1 González Vázquez, Arlyng
A1 Planell i Estany, Josep A.
A1 Engel López, Elisabeth
A1 Buján Varela, Julia
A1 García Honduvilla, Natalio
A1 Vallet Regí, María
K1 Biomateriales - Aplicaciones médicas
AB The current study reports on the manufacturing by rapid prototyping technique of three-dimensional (3D) scaffolds based on silicon substituted hydroxyapatite with Elastin-like Recombinamers (ELRs) func- tionalized surfaces. Silicon doped hydroxyapatite (Si-HA), with Ca10(PO4)5.7(SiO4)0.3(OH)1.7h0.3 nominal formula, was surface functionalized with two different types of polymers designed by genetic engineer- ing: ELR-RGD that contain cell attachment specific sequences and ELR-SNA15/RGD with both hydroxya- patite and cells domains that interact with the inorganic phase and with the cells, respectively. These hybrid materials were subjected to in vitro assays in order to clarify if the ELRs coating improved the well-known biocompatible  and  bone  regeneration  properties  of  calcium  phosphates  materials.  The in vitro tests showed that there was a total and homogeneous colonization of the 3D scaffolds by Bone marrow Mesenchymal Stromal Cells (BMSCs). In addition, the BMSCs were viable and able to proliferate and differentiate into osteoblasts.
PB Elsevier
SN 1742-7061
YR 2016
FD 2016
LK http://uvadoc.uva.es/handle/10324/21699
UL http://uvadoc.uva.es/handle/10324/21699
LA eng
NO Acta Biomaterialia 2016, Elsevier, vol. 45, p. 349–356
NO Producción Científica
DS UVaDOC
RD 18-nov-2024