RT info:eu-repo/semantics/bookPart
T1 Assessment of Effective Connectivity in Alzheimer’s Disease Using Granger Causality
A1 Juan Cruz, Celia
A1 Gómez Peña, Carlos
A1 Poza Crespo, Jesús
A1 Fernández, Alberto
A1 Hornero Sánchez, Roberto
K1 Alzheimer, Enfermedad de
AB Alzheimer’s disease (AD) is a neurological disorder accompanied by cognitive impairment. A complete understanding of the neurological processes involved in AD is a leading challenge in brain research. In this study, resting-state magnetoencephalography (MEG) activity from 36 AD patients and 26 healthy controls was evaluated by means of Granger Causality (GC), an effective connectivity measure that provides an estimation of the information flow between brain regions. Our results showed widespread increments in connectivity in delta (, 1-4 Hz) band. On the other hand, decrements in connectivity patterns were found for theta (, 4-8 Hz), beta (, 13-30 Hz), and gamma (, 30-65 Hz) bands. These findings strength the disconnection hypothesis in AD, and reveal GC as a useful parameter for AD identification.
PB Springer
SN 978-3-319-46668-2
YR 2016
FD 2016
LK http://uvadoc.uva.es/handle/10324/21746
UL http://uvadoc.uva.es/handle/10324/21746
LA eng
NO Converging Clinical and Engineering Research on Neurorehabilitation II. Proceedings of the 3rd International Conference on NeuroRehabilitation (ICNR2016), Editors: Ibáñez, J., González-Vargas, J., Azorín, J.M., Akay, M., Pons, J.L., 2016, p. 763-767 (Biosystems & Biorobotics)
NO Producción Científica
DS UVaDOC
RD 23-nov-2024