RT info:eu-repo/semantics/article
T1 Hybrid elastin-like recombinamer-fibrin gels: physical characterization and in vitro evaluation for cardiovascular tissue engineering applications
A1 González de Torre, Israel
A1 Weber, Miriam T.
A1 Quintanilla Sierra, Luis
A1 Alonso Rodrigo, Matilde
A1 Jockenhoevel, Stefan
A1 Rodríguez Cabello, José Carlos
A1 Mela, Petra
K1 Colágeno
AB In the field of tissue engineering, the properties of the scaffolds are of crucial importance for the success of the application. Hybrid materials combine the properties of the different components that constitute them. In this study hybrid gels of Elastin-Like Recombinamer (ELR) and fibrin were prepared with a range of polymer concentrations and ELR-to-fibrin ratios. The correlation between SEM micrographs, porosities, swelling ratios and rheological properties was discussed and a poroelastic mechanism was suggested to explain the mechanical behavior of the hybrid gels. Applicability as scaffold materials for cardiovascular tissue engineering was shown by the realization of cell-laden matrixes which supported the synthesis of collagens as revealed by immunohistochemical analysis. As a proof of concept, a tissue-engineered heart valve was fabricated by injection moulding and cultivated in a bioreactor for 3 weeks under dynamic con- ditions. Tissue analysis revealed the production of collagen I and III, fundamental proteins for cardio- vascular constructs.
PB Royal Society of Chemistry
SN 2047-4830
YR 2016
FD 2016
LK http://uvadoc.uva.es/handle/10324/21753
UL http://uvadoc.uva.es/handle/10324/21753
LA eng
NO Biomaterials Science,  2016 vol. 4, 1361-1370
NO Producción Científica
DS UVaDOC
RD 26-abr-2024