RT info:eu-repo/semantics/article
T1 Mineralization and bone regeneration using a bioactive elastin-like recombinamer  membrane
A1 Klymov, Alexey
A1 Reza Nejadnik, M.
A1 Alonso Rodrigo, Matilde
A1 Rodríguez Cabello, José Carlos
A1 Walboomers, X. Frank
A1 Mata, Álvaro
K1 Ingeniería Química
AB In the field of tissue engineering, the properties of the scaffolds are of crucial importance for the success of the application. Hybrid materials combine properties of the different components that constitute them. In this study hybrid gels of elastin-like recombinamer (ELR) and fibrin were prepared with a range on polymer concentrations and ELR-to-fibrin ratios. The correlation between SEM micrographs, porosity, swelling ratio and rheological properties was discussed and a poroelastic mechanism was suggested to explain the mechanical behavior of the hybrid gels. Applicability as scaffold material for cardiovascular tissue engineering was shown by the realization of cell-laden matrixes which supported the synthesis of collagens as revealed by immunohistochemical analysis. As a proof of concept, a tissue-engineered heart valve was fabricated by injection moulding and cultivated in a bioreactor for 3 weeks under dynamic conditions. Tissue analysis revealed production of collagen I and III, fundamental proteins for cardiovascular constructs.
SN 0142-9612
YR 2014
FD 2014
LK http://uvadoc.uva.es/handle/10324/21766
UL http://uvadoc.uva.es/handle/10324/21766
LA spa
NO Biomaterials, 2014, Septiembre, vol. 35 n. 29 p. 8339-47
NO Producción Científica
DS UVaDOC
RD 18-nov-2024