RT info:eu-repo/semantics/article
T1 Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
A1 González de Torre, Israel
A1 Quintanilla Sierra, Luis
A1 Pinedo Martín, Guillermo
A1 Rodríguez Cabello, José Carlos
A1 Alonso Rodrigo, Matilde
K1 Nanogeles
AB Diluted, complementary, click-reactive elastin-like recombinamer (ELR) solutions have been prepared and mixed at two different temperatures, one below and one above the characteristic transition temperature (Tt) of these chemically modified ELRs. FTIR measurements, size, aspect ratio, zeta potential, and microrheological measurements have been carried out on the nanostructures formed under these dilute conditions as a way to better understand the relationship between the final macroscopic properties of ELR-based hydrogels and the molecular conditions governing the initial stages of the chemical cross- linking process that occurs, especially its dependence on the preparation temperature relative to Tt. As a result, two different fractal modes of gel formation have been found at the two temperatures studied (above and below Tt). Thus, when the reaction mixture is prepared below Tt, essentially one-dimensional linear nanogels with a high aspect ratio are obtained. In contrast, 3D nanogels are formed above Tt, with spherical shapes predominating. These different structures seem to reflect the two molecular organizations of the single components of the mixture under these conditions, namely extended chains below Tt and a spherical arrangement above Tt. In addition to the interest in these nanogels as models for understanding the formation of microscopicstructures and differential macroscopic properties under more conventional hydrogel-formation conditions, these nanogels are ofinterest because of their thermoresponsiveness and biocompatibility, which provide them with potential uses for drug delivery and other biomedical applications in living systems.
PB American Chemical Society
SN 1944-8244
YR 2014
FD 2014
LK http://uvadoc.uva.es/handle/10324/21773
UL http://uvadoc.uva.es/handle/10324/21773
LA eng
NO ACS Applied Materials and Interfaces. July 2014, vol 6 n. 16. p. 14509-14515
NO Producción Científica
DS UVaDOC
RD 24-nov-2024