RT info:eu-repo/semantics/article
T1 Non-steroidal anti-inflammatory drugs (NSAIDs) and neuroprotection in the elderly: a view from the mitochondria
A1 Calvo Rodríguez, María
A1 Villalobos Jorge, Carlos
A1 Núñez Llorente, Lucía
K1 Mitochondria
AB The most important risk factor for stroke and neurodegeneration isaging. In fact, survival after stroke diminishes largely with aging. Infact, recovery after brain artery occlusion is dramatically worsenedby aging, even normal aging is associated with neuron damage andcognitive decline. Mechanisms involved in aging-related, cognitivedecline and susceptibility to neuron damage in stroke and neurodegenerationare largely unknown. One of the most important mechanismscontributing to neural dysfunction and death is excitotoxicity.This process is based on the fact that the excessive glutamatereceptor stimulation may lead to neuronal damage. This overstimulationmay be due to increased concentration of glutamate, or theprolonged activation of receptors.
PB Medknow Publications
SN 1673-5374
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/21820
UL http://uvadoc.uva.es/handle/10324/21820
LA eng
NO Neural Regen Res 10 (9), 1371-1372.
NO Producción Científica
DS UVaDOC
RD 16-jul-2024