RT info:eu-repo/semantics/article
T1 Clinical, Refractive and Histological Reversibility of Corneal Additive Surgery in Deep Stroma in an Animal Model.
A1 Ibares Frías, Lucía
A1 Gallego Muñoz, Patricia
A1 Cantalapiedra Rodríguez, Roberto
A1 Merayo Lloves, Jesús
A1 Martínez García, María del Carmen
K1 Córnea - Cirugía
AB The aim was to evaluate the reversibility of the clinical and histological changes induced in the corneas of an animal model after removing an intracorneal ring segment (ICRS).Surgery for this study was performed in 38 eyes of an experimental animal model (Gallus domesticus) for ICRS surgery (Ferrara technique). The animals without complications were randomized to two groups; in all of them, 1 segment was implanted in each eye and later removed at different times (1 and 3 months after implantation). In each group, after explantation, corneas were processed at different times for histological analysis with hematoxylin and eosin (H&E) stain and electronic microscopy. The refractive state of the eyes was also measured.In corneas without complications (88.23%), explantation was performed correctly. During the first few days, around the area where the ICRS was implanted we observed deposits of cells and a moderate degree of corneal opacity (haze). These signs decreased progressively without disappearing completely. Histologically, at 7 days, we observed hyperplasia and abnormal arrangement of collagen fibers. Later, these findings also decreased in both groups, albeit at a faster rate in group 1. Minimal changes were observed in electron microscopy up to the end of the study in both groups. Preoperative refractive state was achieved at 1 month after explantation in both groups.ICRS can safely be explanted from the cornea. Refractive reversibility was achieved at 1 month after explantation. However, the clinical and histological findings after ICRS explantation depend on the time from implantation to explantation.
PB Taylor & Francis
SN 0271-3683
YR 2016
FD 2016
LK http://uvadoc.uva.es/handle/10324/22097
UL http://uvadoc.uva.es/handle/10324/22097
LA eng
NO Current eye Research ,(2016); 41(9):1192-1201
NO Producción Científica
DS UVaDOC
RD 19-abr-2024