RT info:eu-repo/semantics/article
T1 Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae)
A1 Castillo, Dagnelia
A1 Arevalo, Jorge
A1 Herrera Gómez, Francisco Magno
A1 Ruiz, Candy
A1 Rojas, R.
A1 Vaisberg, Abraham
A1 Lockb, O.
A1 Lemesre, J.L.
A1 Gornitzka, H.
A1 Sauvain, Michel
K1 Leishmaniasis - Tratamiento
AB Extracts of seven medicinal plants used specifically against cutaneous leishmaniasis in the Madre de Dios region of Peru were evaluated invitro against promastigote and axenic amastigote forms of Leishmania amazonensis. One of them showed interesting leishmanicidal activities(IC50 =5!g/ml in amastigotes). Bio-guided isolation of the stem bark’s ethanol extract of Himatanthus sucuuba (Spruce ex M¨ull. Arg.) Woodson(Apocynaceae) afforded the spirolactone iridoids isoplumericin and plumericin. The latter showed a reduction of macrophage infection similar tothat of the reference drug Amphotericin B (IC50 = 0.9 and 1!M, respectively). These findings validate the traditional use of Himatanthus sucuubain the treatment of cutaneous leishmaniasis (Uta) in Peru.
PB Elsevier
SN 0378-8741
YR 2007
FD 2007
LK http://uvadoc.uva.es/handle/10324/22101
UL http://uvadoc.uva.es/handle/10324/22101
LA eng
NO J Ethnopharmacol, (2007);112(2):410-4
NO Producción Científica
DS UVaDOC
RD 22-nov-2024