RT info:eu-repo/semantics/article
T1 New IL-15 receptor-α splicing variants identified in intestinal epithelial Caco-2 cells
A1 Escudero Hernández, Celia
K1 Cáncer colorrectal
K1 Enfermedad celíaca
K1 Colon irritable
AB IL-15 is a pleiotropic cytokine related to IL-2 which acts at a broader level than its counterpart. It is presented through its specific high-affinity receptor, IL-15Ra. Both cytokine and receptor are tightly regulated at multiple levels and are widely distributed. Thus, deregulation of their expression leads to an inflammatory immune response. Variants of splicing of IL-15Ra have been described in immune and barrier cells; however, their presence has not been focused on intestinal epithelial cells. In this study, we describe five new alternative variants of splicing of IL-15Ra in Caco-2 cells. Four of them were expressed into proteins inside Caco-2 cells, but these were unable to bind IL-15 or to follow the secretory pathway. However, the expression of mRNA itself might be relevant to diseases such as celiac disease, inflammatory bowel disease or colorectal cancer.
PB International Endotoxin and Innate Immunity Society
SN 1753-4259
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/22616
UL http://uvadoc.uva.es/handle/10324/22616
LA eng
NO Innate Immunity, 2017 Vol. 23(1), pp. 44-53
NO Producción Científica
DS UVaDOC
RD 17-jul-2024