RT info:eu-repo/semantics/article
T1 Determination of the temporal order among the components of an oscillatory system
A1 Barragán, Sandra
A1 Rueda Sabater, María Cristina
A1 Fernández Temprano, Miguel Alejandro
A1 Peddada, Shyamal
AB Oscillatory systems in biology are tightly regulated process where the individual components(e.g. genes) express in an orderly manner by virtue of their functions. The temporalorder among the components of an oscillatory system may potentially be disrupted for variousreasons (e.g. environmental factors). As a result some components of the system maygo out of order or even cease to participate in the oscillatory process. In this article, wedevelop a novel framework to evaluate whether the temporal order is unchanged in differentpopulations (or experimental conditions). We also develop methodology to estimate theorder among the components with a suitable notion of “confidence.” Using publicly availabledata on S. pombe, S. cerevisiae and Homo sapiens we discover that the temporal orderamong the genes cdc18; mik1; hhf1; hta2; fkh2 and klp5 is evolutionarily conserved fromyeast to humans.
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/22788
UL http://uvadoc.uva.es/handle/10324/22788
LA eng
NO PLOS ONE 10(7): e0124842
DS UVaDOC
RD 24-nov-2024