RT info:eu-repo/semantics/article
T1 Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel
A1 Fernández Colino, Alicia
A1 Bermúdez, J. M.
A1 Arias Vallejo, Francisco Javier
A1 Quinteros, Daniela A.
A1 Gonzo, E.
K1 Biomateriales - Aplicaciones médicas
AB Transversality between mathematical modeling, pharmacology, and materials science is essential in order to achieve controlled-release systems with advanced properties. In this regard, the area of biomaterials provides a platform for the development of depots that are able to achieve controlled release of a drug, whereas pharmacology strives to find new therapeutic molecules and mathematical models have a connecting function, providing a rational understanding by modeling the parameters that influence the release observed. Herein we present a mechanism which, based on reasonable assumptions, explains the experimental data obtained very well. In addition, we have developed a simple and accurate “lumped” kinetics model to correctly fit the experimentally observed drug release behavior. This lumped model allows us to have simple analytic solutions for the mass and rate of drug release as a function of time without limitations of time or mass of drug released, which represents an important step-forward in the area of in vitro drug delivery when compared to the current state of the art in mathematical modeling. As an example, we applied the mechanism and model to the release data for acetazolamide from a recombinant polymer. Both materials were selected because of a need to develop a suitable ophthalmic formulation for the treatment of glaucoma. The in vitro release model proposed herein provides a valuable predictive tool for ensuring product performance and batch-to-batch reproducibility, thus paving the way for the development of further pharmaceutical devices.
PB Elsevier
SN 0928-4931
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/22848
UL http://uvadoc.uva.es/handle/10324/22848
LA spa
NO Materials Science and Engineering, April 2016, vol. 61, n. 1 , p. 286–292
NO Producción Científica
DS UVaDOC
RD 22-nov-2024