RT info:eu-repo/semantics/article
T1 Recent Contributions of Elastin-Like Recombinamers to Biomedicine and Nanotechnology
A1 Arias Vallejo, Francisco Javier
A1 Santos García, María Mercedes
A1 Fernández Colino, Alicia
A1 Pinedo Martín, Guillermo
A1 Girotti, Alessandra
K1 Biomedical research
K1 Nanotechnology
K1 Elastin-chemistry
K1 Biomimetic Materials-chemistry
K1 Elastin-like recombinamers
K1 Self-assembly
K1 Stimuli-responsive
K1 Tissue-engineering
K1 Surface modification
K1 Drug-delivery
AB Abstract: The emergence of the new scientific field known as nanomedicine is being catalyzed by multiple improvements in nanoscience techniques and significant progress in materials science, especially as regards the testing of novel and sophisticated biomaterials. This conjuncture has furthered the development of promising instruments in terms of detection, bioanalysis, therapy, diagnostics and imaging. Some of the most innovative new biomaterials are protein-inspired biomimetic materials in which modern biotechnology and genetic-engineering techniques complement the huge amount of information afforded by natural protein evolution to create advanced and tailor-made multifunctional molecules. Amongst these protein-based biomaterials, Elastin-like Recombinamers (ELRs) have demonstrated their enormous potential in the fields of biomedicine and nanoscience in the last few years. This broad applicability derives from their unmatched properties, particularly their recombinant and tailor-made nature, the intrinsic characteristics derived from their elastin-based origin (mainly their mechanical properties and ability to self-assemble as a result of their stimuli-responsive behavior), their proven biocompatibility and biodegradability, as well as their versatility as regards incorporating advanced chemical or recombinant modifications into the original structure that open up an almost unlimited number of multifunctional possibilities in this developing field. This article provides an updated review of the recent challenges overcome by using these recombinant biomaterials in the fields of nano- and biomedicine, ranging from nanoscale applications in surface modifications and self-assembled nanostructures to drug delivery and regenerative medicine.
PB Benthan Science
YR 2014
FD 2014
LK http://uvadoc.uva.es/handle/10324/22946
UL http://uvadoc.uva.es/handle/10324/22946
LA eng
NO Current Topics in Medicinal Chemistry 2014;14(6):819-36.
DS UVaDOC
RD 24-nov-2024