RT info:eu-repo/semantics/article
T1 Morphologic and neurochemical alterations in the superior colliculus of the genetically epilepsy-prone hamster (GPG/Vall)
A1 Fuentes Santamaría, Verónica
A1 Alvarado, Juan Carlos
A1 García Atarés, María Natividad
A1 López, Dolores E.
K1 Densitometría
K1 Hamsters
K1 Epilepsia
AB The GPG/Vall hamster is an animal model that exhibits seizures in response to sound stimulation. Since the superior colliculus (SC) is implicated in the neuronal network of audiogenic seizures (AGS) in other forms of AGS, this study evaluated seizure-related anatomical or neurochemical abnormalities in the SC of the GPG/Vall hamster. This involved calbindin (CB) and parvalbumin (PV) immunohistochemistry, densitometric analysis and high performance liquid chromatography in the superficial and deep layers of the SC in control and epileptic animals. Compared to control animals, a reduction in SC volume and a hypertrophy of neurons located in the deep layers of the SC were observed in the epileptic hamster. Although, analysis of CB-immunohistochemistry in the superficial layers did not show differences between groups, analysis of PV-immunostaining in the deep SC revealed an increase in the mean gray level within immunostained neurons as well as a decreased immunostained neuropil in the GPG/Vall hamster as compared to control animals. These alterations were accompanied by a decrease in the levels of GABA and increased levels of taurine in the epileptic animal. These data indicate that the deep SC of the GPG/Vall hamster is structurally abnormal; suggesting its involvement in the neuronal network for AGS.
PB Elsevier
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/23317
UL http://uvadoc.uva.es/handle/10324/23317
LA eng
NO Epilepsy Research, vol.75. p.206-219
NO Producción Científica
DS UVaDOC
RD 26-nov-2024