RT info:eu-repo/semantics/article
T1 The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal
A1 Muñoz, Luis J.
A1 Carballosa Gautam, Melissa M.
A1 Yanowsky, Kira
A1 García Atarés, María Natividad
A1 López, Dolores E.
K1 Epilepsia audiogénica
K1 AFLP
K1 Hamsters
AB GASH:Sal hamster strain and the control Syrian hamsters.The GASH:Sal constitutes an experimental model of reflex epilepsy of audiogenic origin derived from an autosomal recessive disorder. Thus, the GASH:Sal exhibits generalized tonic–clonic seizures, characterized by a short latency period after auditory stimulation, followed by wild running, a convulsive phase, and finally stupor, with origin in the brainstem.The seizure profile of the GASH:Sal is similar to those exhibited by other models of inherited AGS susceptibility, which decreases after six months of age, but the proneness across generations is maintained. The GASH:Sal can be considered a reliable model of audiogenic seizures, suitable to investigate current antiepileptic pharmaceutical treatments as well as novel therapeutic drugs.
PB Elsevier
YR 2016
FD 2016
LK http://uvadoc.uva.es/handle/10324/23318
UL http://uvadoc.uva.es/handle/10324/23318
LA eng
NO Epilepsy Behavior
NO Producción Científica
DS UVaDOC
RD 24-nov-2024