RT info:eu-repo/semantics/article
T1 Artrosis. Etiopatogenia y tratamiento
A1 Sánchez Martín, Miguel María
A2 Ediciones Universidad de Valladolid
AB Osteoarthritis is the most common cause of chronic disability in older adults. Although classicaly considered a �wear and tear� degenerative condition of articular joints, recent studies have demonstrated an inflammatory component to osteoarthritis that includes increased activity of a number of cytokines and chemokines in joint tissues which drive production of matrix degrading enzymes. This article reviews current ways of assessing osteoarthritis progression and what factors potentiate it, structural abnormalities that probably produce pain, new understanding of the genetic of osteoarthritis, and evaluations of new and old treatments. Despite intensive laboratory and clinical investigation, there are no proven disease-modifying therapies for osteoarthritis. Since the disease may progress inexorably to joint destructions, orthopedic surgical procedureshave an important role in the management of osteoarthritis. Surgery in deployed both early in the course of disease as well as later when joint destruction occurs. Surgery may also have a preventive role prior to the onset of osteoarthritis.
SN 0210-6523
YR 2013
FD 2013
LK http://uvadoc.uva.es/handle/10324/23847
UL http://uvadoc.uva.es/handle/10324/23847
LA spa
NO Anales de la Real Academia de Medicina y Cirugía de Valladolid, 2013, N.50, pags.181-201
DS UVaDOC
RD 22-abr-2025