RT info:eu-repo/semantics/article
T1 Synthesis and Characterization of Amide Stationary Phases for the Determination of Sulfonamides by Sequential Injection Chromatography
A1 Islas, Gabriela
A1 Rodríguez, José Antonio
A1 Cruz Borbolla, Julián
A1 Vásquez-Pérez, José M.
A1 Barrado Esteban, Enrique
K1 Density functional theory
K1 Sequential injection chromatography
K1 Solid phase interaction
K1 Sulfonamides
AB The synthesis of amide (butyl, cyclohexyl, and phenyl) modified silica and the use as stationary phases in sequential injection chromatogra-phy are described. The system was tested on the isocratic separation of seven sulfonamides (sulfachloropyridazine, sulfadimethoxine, sulfame-thazine, sulfamethoxazole, sulfamethoxypyridazine, sulfaquinoxaline, and sulfathiazole) using each stationary phase with mobile phases composed of acetonitrile/water at a flow rate of 0.45 mL min−1. A mixed mode retention mechanism of sulfonamides in the stationary phases was obtained, including dipole-dipole, π-π, and hydrogen bonding interactions. The most appropriate phase for the separation of sulfonamides was phenylamide. The chromatographic behavior was confirmed using density functional theory of the interaction between sulfamethoxazole and the stationary phases.
PB Taylor & Francis
SN 0003-2719
YR 2016
FD 2016
LK http://uvadoc.uva.es/handle/10324/24230
UL http://uvadoc.uva.es/handle/10324/24230
LA eng
NO Analytical Letters, 2016 Vol. 49 N. 5 p. 676-689
NO Producción Científica
DS UVaDOC
RD 07-ago-2024