RT info:eu-repo/semantics/article
T1 Chitosan-recombinamer layer-by-layer coatings for multifunctional implants
A1 Govindharajulu, Jeevan Prasaad
A1 Rodríguez Cabello, José Carlos
A1 Battacharya, Mrinal
A1 Aparicio, Conrado
K1 Implante dental
AB The main clinical problems for dental implants are (1) formation of biofilm around the implant—a condition known as peri-implantitis and (2) inadequate bone formation around the implant—lack of osseointegration. Therefore, developing an implant to overcome these problems is of significant interest to the dental community. Chitosan has been reported to have good biocompatibility and anti-bacterial activity. An osseo-inductive recombinant elastin-like biopolymer (P-HAP), that contains a peptide derived from the protein statherin, has been reported to induce biomineralization and osteoblast differentiation. In this study, chitosan/P-HAP bi-layers were built on a titanium surface using a layer-by-layer (LbL) assembly technique. The difference in the water contact angle between consecutive layers, the representative peaks in diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), X-ray photoelectron spectroscopy (XPS), and the changes in the topography between surfaces with a different number of bi-layers observed using atomic force microscopy (AFM), all indicated the successful establishment of chitosan/P-HAP LbL assembly on the titanium surface. The LbL-modified surfaces showed increased biomineralization, an appropriate mouse pre-osteoblastic cell response, and significant anti-bacterial activity against Streptococcus gordonii, a primary colonizer of tissues in the oral environment
PB MDPI
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/24420
UL http://uvadoc.uva.es/handle/10324/24420
LA eng
NO International Journal of Molecular Sciences 2017, 18 (2), 369;
NO Producción Científica
DS UVaDOC
RD 17-jul-2024