RT info:eu-repo/semantics/article
T1 Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells
A1 López Barneo, José
A1 López López, José Ramón
A1 Ureña, J.
A1 González, Constancio
K1 Cuerpo carotídeo
K1 Neurotransmisores
AB The ionic currents of carotid body type 1cells and their possible involvement in the detection of oxygen tension (Po2) in arterial blood are unknown. The electrical properties of these cells were studied with the whole-cell patch clamp technique, and the hypothesis that ionic conductances can bealtered by changes in Po2 was tested. The results show that type 1cells have voltage-dependent sodium, calcium, and potassium channels. Sodium and calcium currents were unaffected by a decrease in Po2 from 150 to 10 millimeters of mercury, whereas, with the same experimental protocol, potassi­ um currents were reversibly reduced by 25 to 50 percent. The effect of hypoxia was independent of internal adenosine triphosphate and calcium. Thus, ionic conductances, and particularly the 02-sensitive potassium current, play a key role in the transduction mechanism of arterial chemoreceptors.
PB American Association for the Advancement of Science
SN 0036-8075
YR 1988
FD 1988
LK http://uvadoc.uva.es/handle/10324/24717
UL http://uvadoc.uva.es/handle/10324/24717
LA spa
NO Science, vol. 241. p.580-582.
NO Producción Científica
DS UVaDOC
RD 22-nov-2024