RT info:eu-repo/semantics/article
T1 Elastin-like polypeptides in drug delivery
A1 Rodríguez Cabello, José Carlos
A1 Arias Vallejo, Francisco Javier
A1 Alonso Rodrigo, Matilde
A1 Girotti, Alessandra
AB The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-delivery applications is reviewed in this work. Although ELRs were initially used in similar ways to other, more conventional kinds of polymeric carriers, their unique properties soon gave rise to systems of unparalleled functionality and efficiency, with the stimuli responsiveness of ELRs and their ability to self-assemble readily allowing the creation of advanced systems. However, their recombinant nature is likely the most important factor that has driven the current breakthrough properties of ELR-based delivery systems. Recombinant technology allows an unprecedented degree of complexity in macromolecular design and synthesis. In addition, recombinant materials easily incorporate any functional domain present in natural proteins. Therefore, ELR-based delivery systems can exhibit complex interactions with both their drug load and the tissues and cells towards which this load is directed. Selected examples, ranging from highly functional nanocarriers to macrodepots, will be presented.
PB Elsevier
YR 2016
FD 2016
LK http://uvadoc.uva.es/handle/10324/24759
UL http://uvadoc.uva.es/handle/10324/24759
LA eng
NO Advanced Drug Delivery Reviews Volume 97, 1 February 2016, Pages 85-100
NO Producción Científica
DS UVaDOC
RD 24-abr-2024