RT info:eu-repo/semantics/article
T1 Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
A1 Singh, Smriti
A1 Rahimi, Khosrow
A1 Fechete, Radu
A1 Rodríguez Cabello, José Carlos
A1 Möller, Martin
K1 Agregación de microgeles biohíbridos
AB Investigation of the aggregation behavior of biohybrid microgels, which can potentially be used as drug carriers, is an important topic, because aggregation not only causes loss of activity, but also toxicity and immunogenicity. To study this effect we synthesized microgels from elastin-like recombinamers (ELRs) using the miniemulsion technique. The existence of aggregation for such biohybrid microgels at different concentrations and temperatures was studied by different methods which include dynamic light scattering (DLS), 1H high-resolution magic angle sample spinning (HRMAS) NMR spectroscopy, relaxometry and diffusometry. A hysteresis effect was detected in the process of aggregation by DLS as a function of temperature that strongly depends on ELR microgel concentration. The aggregation process was further quantitatively analyzed by the concentration dependence of the 1H amino-acid residue chemical shifts and microgel diffusivity measured by NMR methods using the population balance kinetic aggregation model.
PB Royal Society of Chemistry
YR 2016
FD 2016
LK http://uvadoc.uva.es/handle/10324/24800
UL http://uvadoc.uva.es/handle/10324/24800
LA eng
NO Soft Matter, 2016,12, pg. 6240-6252
NO Producción Científica
DS UVaDOC
RD 22-nov-2024