RT info:eu-repo/semantics/bookPart
T1 Ionic Mechanisms of the Chemoreception Process in Type 1 Cells of the Carotid Body
A1 González, Constancio
A1 Rocher Martín, María Asunción
A1 Obeso Cáceres, Ana María de la Luz
A1 López López, José Ramón
A1 López Barneo, José
A1 Herreros Guilarte, Benito
K1 Cuerpo carotídeo
K1 Receptores celulares
K1 Neurotransmisores
AB Tbe receptor complex in the carotid body (CB) is formed by clusters of type 1 cells that are connected synaptically to the endings of the chemo­ sensory fibers of the carotid sinus nerve (CSN), partia lly covered by type JI cells, and surrounded by a dense net of fenestrated capillaries (1).Sorne aspects of CB chemoreceptor physiology such as the identity of adequate stimulus, the characteristics of the receptor response to the dif­ ferent stimuli, and the reflex responses elicited upon CB stimulation are well known. Contrary  to this, the basic mechanisms operating in this re­ ceptor are not completely understood (2). It has been proposed that low Po2 will decrease the ATP leveIs in the chemoreceptor or type 1cells and that this decrease in ATP  will trigger the release of neurotransm itters capable  of  activating  the sensory nerve endings.  However,  there  is noproposal on how the decrease in ATP levels can activate the release process. It  has been  proposed  also that  high  Pco2  and/or low  pH  in blood  will increase the intracellular H+  concentration  and that it will result i n in­ creased intracellu lar Ca2 + in type 1 cells and in the release of transmitters. Once again , there is no proposal on the mechanisms by which the increase in H+ can produce the increased Ca2+ concentration in type I cells (2,3).
PB Springer Verlag
YR 1990
FD 1990
LK http://uvadoc.uva.es/handle/10324/24835
UL http://uvadoc.uva.es/handle/10324/24835
LA eng
NO Arterial Chemoreception. New York, 1990, p. 44-57
NO Producción Científica
DS UVaDOC
RD 27-nov-2024