RT info:eu-repo/semantics/bookPart
T1 Intracellular Ca2 + deposits and catecholamine secretion by chemoreceptor cells of the rabbit carotid body
A1 Obeso Cáceres, Ana María de la Luz
A1 Rocher Martín, María Asunción
A1 López López, José Ramón
A1 González, Constancio
K1 Cuerpo carotídeo - Conejos
K1 Hemoreceptores
AB The pívotal role  of íntracellular free [Ca2+] fluctuatíons in the control of cellular functíons such as contraction and secretíon, íncludíng the release of neurotransmítters, was recognized many decades ago (see Rubín, 1982). More recently, the list of cellular functíons tríggered or modulated by the levels of Ca2+¡ has grown enormously. Addítional functíons regulated by [Ca2+)¡ include neuronal excítabílity, synaptic plastícíty, gene ex­ pressíon, cellular metabolísm, cell dívísíon and dífferentíatíon, and programmed cell dead (Míller, 1991; Clapham, 1995). Parallelíng the growth in this líst of Ca2+-controlled func­ tíons, a multíplicity of cellular mechanísms aimed at maintaining resting free [Ca2+)¡ in the range of l 00 nM for most cells has been described, allowing increases in Ca2+¡ levels that are specific in their magnitude, time course and spatial distributíon, accordíng to the cell function activated (Toescu, 1995).Since Ca2+ cannot be metabolized, cells regulate theír cytoplasmic levels of free Ca2+ through numerous bínding proteíns and influx and efflux mechanisms (Fíg 1). Ca2+ ínflux to cell cytoplasm from the extracellular milieu occurs vía voltage or receptor operated channels or vía yet ill-defined  capacítatíve pathways;  the Na+/Ca 2+ exchanger  can also produce in sorne círcumstances net ínflux of Ca2+ (Míller, 1991; Clapham, 1995). Ca2+ ef­ flux to the extracellular space occurs against electrochemical gradíents, and thereby the pumpíng out of Ca2+ is directly (Caz+ pump) or indirectly (Na+/Ca2+) coupled to the hy­ drolysis of ATP.
PB Plenum Press
YR 1996
FD 1996
LK http://uvadoc.uva.es/handle/10324/25055
UL http://uvadoc.uva.es/handle/10324/25055
LA eng
NO Zapata et al. (eds.). Frontiers in Arterial Chemoreception. New York, 1996, p.279-284.
NO Producción Científica
DS UVaDOC
RD 27-nov-2024