RT info:eu-repo/semantics/article
T1 Preparation of cellulose aerogels from ionic liquid solutions for supercritical impregnation of phytol
A1 Lopes, Joana
A1 Mustapa, Ana Najwa Binti
A1 Pantic, Milica
A1 Bermejo Roda, Maria Dolores
A1 Martín Martínez, Ángel
A1 Novak, Zoran
A1 Knez, Zeljko
A1 Cocero Alonso, María José
K1 Materiales
K1 Supercritical
K1 Impregnation
K1 Aerogel
K1 Phytol
K1 Cellulose
K1 Ionic liquids
AB The use of natural polysaccharides is especially attractive to the pharmaceutical industry because of their stability, availability, renewability and low toxicity. In this study, cellulose aerogels obtained from cellulose/ionic liquid solutions were prepared by supercritical drying with surface areas ranged from 154 to 434 m2 g−1, pore volume from 0.3 to 2.4 cm3 g−1 and pore diameter from 7.9 to 34 nm. Drug loading capacity was investigated by impregnating phytol as model compound into the aerogels, using supercritical CO2 at 100 bar, 40 °C and mass ratio of phytol per gram of aerogel 10:1. The quantity of drug present is consistent in each aerogel. The aerogel prepared from 2 wt% cellulose in [Emim][DEP] solution showed the highest loading capacity. The high amount of drug loaded (approx 50% w/w) in the cellulose aerogels prepared from ionic liquid solutions shows their potential uses in the pharmaceutical or medical industry.
PB Elsevier B.V.
SN 0896-8446
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/26138
UL http://uvadoc.uva.es/handle/10324/26138
LA eng
NO The Journal of Supercritical Fluids, Diciembre 2017, vol 130, p. 17-22
NO Producción Científica
DS UVaDOC
RD 24-dic-2024