RT info:eu-repo/semantics/article
T1 Nanotechnological Approaches to Therapeutic Delivery Using Elastin-Like Recombinamers
A1 Rodríguez Cabello, José Carlos
A1 Piña, María Jesús
A1 Ibáñez Fonseca, Arturo
A1 Fernández Colino, Alicia
A1 Arias Vallejo, Francisco Javier
K1 Fármacos
K1 Elastina
AB This Review discusses the use of elastin-like polymers and their recombinant version, elastin-like recombinamers, in drug-delivery systems. These macromolecules exhibit a number of interesting properties that are rarely found together in any other family of materials, especially extremely high biocompatibility, high bioactivity and functionality, complex yet fully controlled composition, and stimuli responsiveness. Appropriate design of these molecules opens up a broad range of different possibilities for their use in new therapeutic platforms. The first of these described herein is the use of ELRs in single-molecule devices as therapeutic entities in their own right. Subsequently, we describe how the self-assembly properties of these materials can be exploited to create nanocarriers and, eventually, microcarriers that are able to temporally and spatially control and direct the release of their drug load. Intracellular drug-delivery devices and nanocarriers for treating cancer are among the uses described in that section. Finally, the use of ELRs as base materials for implantable drug depots, in the form of hydrogels, is discussed.
PB American Chemical Society
SN 1043-1802
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/27585
UL http://uvadoc.uva.es/handle/10324/27585
LA eng
NO Bioconjugate Chemistry, 2015, 26 (7), p. 1252–1265
NO Producción Científica
DS UVaDOC
RD 08-ago-2024