RT info:eu-repo/semantics/article
T1 Recombinant Technology in the Development of Materials and Systems for Soft-Tissue Repair
A1 Girotti, Alessandra
A1 Orbanic, Doriana
A1 Ibáñez Fonseca, Arturo
A1 González Obeso, Constancio
A1 Rodríguez Cabello, José Carlos
K1 Tejidos blandos
K1 Tecnología recombinante
AB The field of biomedicine is constantly investing significant research efforts in order to gain a more in-depth understanding of the mechanisms that govern the function of body compartments and to develop creative solutions for the repair and regeneration of damaged tissues. The main overall goal is to develop relatively simple systems that are able to mimic naturally occurring constructs and can therefore be used in regenerative medicine. Recombinant technology, which is widely used to obtain new tailored synthetic genes that express polymeric protein-based structures, now offers a broad range of advantages for that purpose by permitting the tuning of biological and mechanical properties depending on the intended application while simultaneously ensuring adequate biocompatibility and biodegradability of the scaffold formed by the polymers. This Progress Report is focused on recombinant protein-based materials that resemble naturally occurring proteins of interest for use in soft tissue repair. An overview of recombinant biomaterials derived from elastin, silk, collagen and resilin is given, along with a description of their characteristics and suggested applications. Current endeavors in this field are continuously providing more-improved materials in comparison with conventional ones. As such, a great effort is being made to put these materials through clinical trials in order to favor their future use.
PB Wiley Online Library
SN 2192-2659
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/27590
UL http://uvadoc.uva.es/handle/10324/27590
LA eng
NO Advanced Healthcare Materials, 2015, Volume 4, Issue 16, p. 2423–2455
NO Producción Científica
DS UVaDOC
RD 23-nov-2024