RT info:eu-repo/semantics/article
T1 Influence of aspirin therapy in the ulcer associated with chronic venous insufficiency
A1 Río Sola, María Lourdes del
A1 González Fajardo, José Antonio
A1 Vaquero Puerta, Carlos
K1 Insuficiencia venosa crónica
K1 Aspirina
K1 Úlceras
AB Background: To determine the effect of aspirin on ulcer healing rate in patients with chronicvenous insufficiency, and to establish prognostic factors that influence ulcer evolution.Methods: Between 2001 and 2005, 78 patients with ulcerated lesions of diameter >2 cm andassociated with chronic venous insufficiency were evaluated in our hospital. Of these, 51 patients(22 men, 29 women) with mean age of 60 years (range: 36e86) were included in a prospectiverandomized trial with a parallel control group. The treatment group received 300 mg of aspirin andthe control group received no drug treatment; in both groups, healing was associated with standardcompression therapy. During follow-up, held weekly in a blinded fashion, there was ulcerhealing as well as cases of recurrence. Results were analyzed by intention-to-treat approach.Cure rate was estimated using KaplaneMeir survival analysis, and the influence of prognosticfactors was analyzed by applying the Cox proportional hazards model.Results: In the presence of gradual compression therapy, healing occurred more rapidly inpatients receiving aspirin versus the control subjects (12 weeks in the treated group vs. 22weeks in the control group), with a 46% reduction in healing time. The main prognostic factorwas estimated initial area of injury (P ¼ 0.032). Age, sex, systemic therapy, and infectionshowed little relevance to evolution.Conclusions: The administration of aspirin daily dose of 300 mg shortens the healing time ofulcerated lesions in the chronic venous insufficiency (CVI). The main prognostic factor for healingof venous ulcerated lesions is the initial surface area of the ulcer.
PB Universidad de Valladolid. Facultad de Medicina
YR 2012
FD 2012
LK http://uvadoc.uva.es/handle/10324/2904
UL http://uvadoc.uva.es/handle/10324/2904
LA eng
NO Annals of Vascular Surgery
NO Producción Científica
DS UVaDOC
RD 23-nov-2024